M H Bublitz1,2,3,4, M Carpenter1,3,4, S Amin1,3,5, M L Okun6, R Millman1,5,7, S M De La Monte1,5,8, G Bourjeily1,3,4. 1. Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, USA. 2. Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, USA. 3. Department of Medicine, The Miriam Hospital, Providence, USA. 4. Women's Medicine Collaborative of Lifespan, Providence, USA. 5. Department of Medicine, Rhode Island Hospital, Rhode Island Hospital, Providence, USA. 6. Lane Center for Academic Health Sciences, Clinical and Biobehavioral Research, University of Colorado, Colorado Springs, USA. 7. Sleep Disorders Center of Lifespan Hospitals, Providence, USA. 8. Department of Pathology (Neuropathology), Rhode Island Hospital, Providence, USA.
Abstract
BACKGROUND: Obstructive sleep apnea is associated with pregnancy complications including gestational diabetes. Mechanisms underlying the association between obstructive sleep apnea and gestational diabetes remain to be elucidated. METHODS: Twenty-three participants with gestational diabetes underwent home sleep apnea testing. Obstructive sleep apnea was defined as an apnea hypopnea index > 5. Fasting morning blood samples were measured using multianalyte profiling (xMAP) multiplexed bead array immunoassay for Interleukin 6, tumor necrosis factor-alpha, and Interleukin 8. RESULTS: Age, body mass index, and gestational age at enrollment were 31 + 4.4 years, 35.7 + 7.4 kg/m2, and 28 ± 4 weeks, respectively. Participants were 52% Caucasian and 16% had obstructive sleep apnea. We observed positive correlations between apnea hypopnea index and Interleukin 6 (r = 0.62, p = 0.005), Interleukin 8 (r = 0.56, p = .56), and tumor necrosis factor-alpha (r = .58, p = .009). Women with obstructive sleep apnea had higher levels of Interleukin 6 (F = 5.01, p = .037) and Interleukin 8 (F = 6.33, p = .021) vs. women without obstructive sleep apnea. CONCLUSION: These preliminary results indicate that in women with gestational diabetes, apnea hypopnea index is associated with an elevated inflammatory profile.
BACKGROUND: Obstructive sleep apnea is associated with pregnancy complications including gestational diabetes. Mechanisms underlying the association between obstructive sleep apnea and gestational diabetes remain to be elucidated. METHODS: Twenty-three participants with gestational diabetes underwent home sleep apnea testing. Obstructive sleep apnea was defined as an apnea hypopnea index > 5. Fasting morning blood samples were measured using multianalyte profiling (xMAP) multiplexed bead array immunoassay for Interleukin 6, tumor necrosis factor-alpha, and Interleukin 8. RESULTS: Age, body mass index, and gestational age at enrollment were 31 + 4.4 years, 35.7 + 7.4 kg/m2, and 28 ± 4 weeks, respectively. Participants were 52% Caucasian and 16% had obstructive sleep apnea. We observed positive correlations between apnea hypopnea index and Interleukin 6 (r = 0.62, p = 0.005), Interleukin 8 (r = 0.56, p = .56), and tumor necrosis factor-alpha (r = .58, p = .009). Women with obstructive sleep apnea had higher levels of Interleukin 6 (F = 5.01, p = .037) and Interleukin 8 (F = 6.33, p = .021) vs. women without obstructive sleep apnea. CONCLUSION: These preliminary results indicate that in women with gestational diabetes, apnea hypopnea index is associated with an elevated inflammatory profile.
Authors: Helen S Driver; Effie J Pereira; Kathryn Bjerring; Fern Toop; Steven C Stewart; Peter W Munt; Michael F Fitzpatrick Journal: Can Respir J Date: 2011 May-Jun Impact factor: 2.409
Authors: Judette Louis; Dennis Auckley; Branko Miladinovic; Anna Shepherd; Patricia Mencin; Deepak Kumar; Brian Mercer; Susan Redline Journal: Obstet Gynecol Date: 2012-11 Impact factor: 7.661
Authors: Richard B Berry; Rohit Budhiraja; Daniel J Gottlieb; David Gozal; Conrad Iber; Vishesh K Kapur; Carole L Marcus; Reena Mehra; Sairam Parthasarathy; Stuart F Quan; Susan Redline; Kingman P Strohl; Sally L Davidson Ward; Michelle M Tangredi Journal: J Clin Sleep Med Date: 2012-10-15 Impact factor: 4.062
Authors: Sirimon Reutrakul; Nausheen Zaidi; Kristen Wroblewski; Helen H Kay; Mahmoud Ismail; David A Ehrmann; Eve Van Cauter Journal: J Clin Endocrinol Metab Date: 2013-08-21 Impact factor: 5.958
Authors: Giovanni Cizza; Paolo Piaggi; Eliane A Lucassen; Lilian de Jonge; Mary Walter; Megan S Mattingly; Heather Kalish; Gyorgy Csako; Kristina I Rother Journal: PLoS One Date: 2013-05-29 Impact factor: 3.240
Authors: Miguel Angel Luque-Fernandez; Paul A Bain; Bizu Gelaye; Susan Redline; Michelle A Williams Journal: Diabetes Care Date: 2013-10 Impact factor: 19.112
Authors: Laura Sanapo; Margaret H Bublitz; Alice Bai; Niharika Mehta; Geralyn M Messerlian; Patrick Catalano; Ghada Bourjeily Journal: Sleep Date: 2022-04-11 Impact factor: 6.313
Authors: Bingqian Zhu; Ulf G Bronas; David W Carley; Kathryn Lee; Alana Steffen; Mary C Kapella; Bilgay Izci-Balserak Journal: Ann N Y Acad Sci Date: 2020-05-28 Impact factor: 5.691
Authors: Amanda M Vanderplow; Bailey A Kermath; Cassandra R Bernhardt; Kimberly T Gums; Erin N Seablom; Abigail B Radcliff; Andrea C Ewald; Mathew V Jones; Tracy L Baker; Jyoti J Watters; Michael E Cahill Journal: PLoS Biol Date: 2022-02-03 Impact factor: 8.029
Authors: Oleksandr Serednytskyy; Alberto Alonso-Fernández; Caterina Ribot; Andrea Herranz; Ainhoa Álvarez; Andrés Sánchez; Paula Rodríguez; Ana V Gil; Carla Pía; José P Cubero; María Barceló; María Cerdà; Mercedes Codina; Mónica D Peña; Antònia Barceló; Amanda Iglesias; Daniel Morell-Garcia; José A Peña; María P Giménez; María C Piñas; Francisco García-Río Journal: BMC Pulm Med Date: 2022-03-18 Impact factor: 3.317
Authors: Margaret H Bublitz; Laura G Ward; Meera Simoes; Laura R Stroud; Myriam Salameh; Ghada Bourjeily Journal: Psychosom Med Date: 2020-10 Impact factor: 3.864
Authors: Emma C Johns; Elizabeth A Hill; Stevie Williams; AbdelKebir Sabil; Renata L Riha; Fiona C Denison; Rebecca M Reynolds Journal: J Clin Sleep Med Date: 2022-02-01 Impact factor: 4.062