| Literature DB >> 3057368 |
Abstract
Mechanisms of the defense system against genotoxic damage, with emphasis on free-radical processes, are presented. Components of the defense system, interrelationships between components, and the stages in defense are discussed. Examples of free-radical mechanisms of protective agents (mannitol, DMSO) and repair agents (thiols and antioxidants), and the kinetics of their reactions are reviewed. Future trends in the development of novel protective agents are invoked.Entities:
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Year: 1988 PMID: 3057368 DOI: 10.1016/0027-5107(88)90199-6
Source DB: PubMed Journal: Mutat Res ISSN: 0027-5107 Impact factor: 2.433