Hongchen Zheng1, Nan Li1,2, Yongxiu Hao1,2, Chuyao Jin1, Ying Meng1, Shanshan Yao1, Jing Wei1, Yaquan Pan1, Suhong Gao3, Zhiwen Li1,2, Xiaohong Liu3. 1. Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, Peking University Health Science Center, Peking, China. 2. Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Peking, China. 3. Beijing Haidian Maternal and Child Health Hospital, Beijing, China.
Abstract
Objective: The objective of this study is to assess whether maternal stressful life events are associated with increased risk of vaginal bleeding in urban China. Methods: We implemented a cross-sectional study to examine the association between maternal severe stressful life events and vaginal bleeding in early pregnancy. Information was collected from an urban area and 956 participants were involved in final analysis. Multivariable logistic model was used to estimate the adjusted odds ratio (OR) and 95% confidence interval (95% CI) controlling for confounders. Results: In total, 219 of the 956 participants were reported vaginal bleeding. Maternal stressful life events would increase the chance of vaginal bleeding with a crude OR of 2.14 (95% CI, 1.53-2.99). After adjustment for potential variables, the association remains significant (adjusted OR, 2.22; 95% CI, 1.56-3.16), and stratification analysis shows parity is an influence factor. The frequency of maternal stress and vaginal bleeding exist a dose-response relationship. Conclusion: Maternal stressful life events are associated with the risk of vaginal bleeding in urban China. The parity status influences their association.
Objective: The objective of this study is to assess whether maternal stressful life events are associated with increased risk of vaginal bleeding in urban China. Methods: We implemented a cross-sectional study to examine the association between maternal severe stressful life events and vaginal bleeding in early pregnancy. Information was collected from an urban area and 956 participants were involved in final analysis. Multivariable logistic model was used to estimate the adjusted odds ratio (OR) and 95% confidence interval (95% CI) controlling for confounders. Results: In total, 219 of the 956 participants were reported vaginal bleeding. Maternal stressful life events would increase the chance of vaginal bleeding with a crude OR of 2.14 (95% CI, 1.53-2.99). After adjustment for potential variables, the association remains significant (adjusted OR, 2.22; 95% CI, 1.56-3.16), and stratification analysis shows parity is an influence factor. The frequency of maternal stress and vaginal bleeding exist a dose-response relationship. Conclusion: Maternal stressful life events are associated with the risk of vaginal bleeding in urban China. The parity status influences their association.
Authors: Ching-Fang Lee; Fur-Hsing Wen; Yvonne Hsiung; Jian-Pei Huang; Chun-Wei Chang; Hung-Hui Chen Journal: Int J Environ Res Public Health Date: 2021-06-11 Impact factor: 3.390