Jia Qin1, Nicholas Rinella1, Qinqin Zhang2, Hao Zhou2, Jessica Wong1, Michael Deiner1, Austin Roorda3, Travis C Porco1,4, Ruikang K Wang2, Daniel M Schwartz1, Jacque L Duncan1. 1. Department of Ophthalmology, University of California, San Francisco, California, United States. 2. Department of Bioengineering, University of Washington, Seattle, Washington, United States. 3. School of Optometry and Vision Science Graduate Group, University of California, Berkeley, California, United States. 4. Francis I. Proctor Foundation, University of California, San Francisco, California, United States.
Abstract
Purpose: To compare cone spacing and choriocapillaris (CC) perfusion adjacent to geographic atrophy (GA) in patients with age-related macular degeneration (AMD) and age-similar normal eyes. Methods: Subjects were imaged using adaptive optics scanning laser ophthalmoscopy (AOSLO), fundus autofluorescence (FAF), and swept-source optical coherence tomography angiography. The GA border was identified using FAF images; CC flow void was analyzed in 1° regions extending from the GA border. A grader masked to CC perfusion selected regions of interest (ROIs) with unambiguous cone mosaics in AOSLO images. At each ROI, cone spacing and CC flow void were converted to Z-scores (standard deviations from the mean of 12 normal eyes aged 50 to 81 years for cone spacing, and 60 normal eyes age 51 to 88 years for CC flow void). Results: Excluding regions of GA and drusen, CC flow void in eight eyes of six patients with AMD was significantly greater than in four age-similar normal eyes (exact permutation test, P = 0.024). CC flow void was negatively correlated with distance from the GA margin (r = -0.35; 95% confidence interval [CI], -0.53 to -0.12). Increased cone spacing was significantly correlated with CC flow void (r = 0.33; 95% CI, 0.12 to 0.59). Cone spacing was increased in 39% of ROIs, while CC flow void was increased in 96% of ROIs. Conclusions: In eyes with GA due to AMD, CC hypoperfusion was significantly correlated with, and more extensive than, cone photoreceptor loss. The results suggest that reduced CC perfusion contributes to the development of GA.
Purpose: To compare cone spacing and choriocapillaris (CC) perfusion adjacent to geographic atrophy (GA) in patients with age-related macular degeneration (AMD) and age-similar normal eyes. Methods: Subjects were imaged using adaptive optics scanning laser ophthalmoscopy (AOSLO), fundus autofluorescence (FAF), and swept-source optical coherence tomography angiography. The GA border was identified using FAF images; CC flow void was analyzed in 1° regions extending from the GA border. A grader masked to CC perfusion selected regions of interest (ROIs) with unambiguous cone mosaics in AOSLO images. At each ROI, cone spacing and CC flow void were converted to Z-scores (standard deviations from the mean of 12 normal eyes aged 50 to 81 years for cone spacing, and 60 normal eyes age 51 to 88 years for CC flow void). Results: Excluding regions of GA and drusen, CC flow void in eight eyes of six patients with AMD was significantly greater than in four age-similar normal eyes (exact permutation test, P = 0.024). CC flow void was negatively correlated with distance from the GA margin (r = -0.35; 95% confidence interval [CI], -0.53 to -0.12). Increased cone spacing was significantly correlated with CC flow void (r = 0.33; 95% CI, 0.12 to 0.59). Cone spacing was increased in 39% of ROIs, while CC flow void was increased in 96% of ROIs. Conclusions: In eyes with GA due to AMD, CC hypoperfusion was significantly correlated with, and more extensive than, cone photoreceptor loss. The results suggest that reduced CC perfusion contributes to the development of GA.
Authors: Kang Zhang; Jill J Hopkins; Jeffrey S Heier; David G Birch; Lawrence S Halperin; Thomas A Albini; David M Brown; Glenn J Jaffe; Weng Tao; George A Williams Journal: Proc Natl Acad Sci U S A Date: 2011-03-28 Impact factor: 11.205
Authors: Emily Y Chew; Traci E Clemons; Elvira Agrón; Robert D Sperduto; John Paul Sangiovanni; Matthew D Davis; Frederick L Ferris Journal: JAMA Ophthalmol Date: 2014-03 Impact factor: 7.389
Authors: Daniel M Schwartz; Jeff Fingler; Dae Yu Kim; Robert J Zawadzki; Lawrence S Morse; Susanna S Park; Scott E Fraser; John S Werner Journal: Ophthalmology Date: 2013-10-21 Impact factor: 12.079
Authors: Frederick L Ferris; C P Wilkinson; Alan Bird; Usha Chakravarthy; Emily Chew; Karl Csaky; SriniVas R Sadda Journal: Ophthalmology Date: 2013-01-16 Impact factor: 12.079
Authors: Qinqin Zhang; Fang Zheng; Elie H Motulsky; Giovanni Gregori; Zhongdi Chu; Chieh-Li Chen; Chunxia Li; Luis de Sisternes; Mary Durbin; Philip J Rosenfeld; Ruikang K Wang Journal: Invest Ophthalmol Vis Sci Date: 2018-01-01 Impact factor: 4.799
Authors: Inês Laíns; Jay Wang; Joana Providência; Steven Mach; Pedro Gil; João Gil; Marco Marques; Grayson Armstrong; Shady Garas; Patrícia Barreto; Ivana K Kim; Demetrios G Vavvas; Joan W Miller; Deeba Husain; Rufino Silva; John B Miller Journal: Am J Ophthalmol Date: 2017-06-01 Impact factor: 5.258
Authors: Frank Brodie; Michael Repka; Stephen Allan Burns; S Grace Prakalapakorn; Christie Morse; Joel S Schuman; Michael R Duenas; Natalie Afshari; John S Pollack; Jennifer E Thorne; Albert Vitale; H Nida Sen; David Myung; Mark S Blumenkranz; Elmer Tu; Daniel X Hammer; Michelle Tarver; Bradley Cunningham; Larry Kagemann; SriniVas Sadda; David Sarraf; Glenn J Jaffe; Malvina Eydelman Journal: JAMA Ophthalmol Date: 2021-01-01 Impact factor: 7.389
Authors: Sean F Hackett; Jie Fu; Yoo Chun Kim; Hiroki Tsujinaka; Jikui Shen; Raquel Lima E Silva; Mahmood Khan; Zibran Hafiz; Tao Wang; Matthew Shin; Nicole M Anders; Ping He; Laura M Ensign; Justin Hanes; Peter A Campochiaro Journal: Biomaterials Date: 2020-03-04 Impact factor: 12.479
Authors: Jared Hamwood; David Alonso-Caneiro; Danuta M Sampson; Michael J Collins; Fred K Chen Journal: Transl Vis Sci Technol Date: 2019-11-12 Impact factor: 3.283
Authors: Ethan A Rossi; Nathaniel Norberg; Chiara Eandi; Celine Chaumette; Saloni Kapoor; Laura Le; Valerie C Snyder; Joseph N Martel; Josselin Gautier; Kiyoko Gocho; Kunal K Dansingani; Jay Chhablani; Angelo Arleo; Sarah Mrejen; José-Alain Sahel; Kate Grieve; Michel Paques Journal: Transl Vis Sci Technol Date: 2021-12-01 Impact factor: 3.048
Authors: Jonathan Li; Hao Zhou; Max Feinstein; Jessica Wong; Ruikang K Wang; Lawrence Chan; Yining Dai; Travis Porco; Jacque L Duncan; Daniel M Schwartz Journal: Transl Vis Sci Technol Date: 2022-02-01 Impact factor: 3.048
Authors: Christopher K Hwang; Elvira Agrón; Amitha Domalpally; Catherine A Cukras; Wai T Wong; Emily Y Chew; Tiarnan D L Keenan Journal: Ophthalmol Retina Date: 2020-10-16