OBJECTIVE: High BMI predicts adverse cardiovascular outcomes and positively correlates with increased levels of adipokines. The relationship among BMI, IL-6, TNFα, adiponectin, and oxidized high-density lipoprotein (Ox-HDL) with circulating endothelial cells (CECs) and endothelial progenitor cells (EPCs) has not been well studied. Elevated CEC levels have been described in both humans and mice with obesity and diabetes. Ox-HDL has been shown to be a potent driver of adipogenesis in vivo and in vitro. In this study, elevated BMI was examined in 2 groups of women studied in Brooklyn, New York, and Huntington, West Virginia, respectively. METHODS: Twenty-six females with obesity and five lean controls without overt cardiovascular disease were enrolled, 13 from Huntington and 13 from Brooklyn. Cytokine levels, EPCs, and CECs were determined. RESULTS: Females with obesity had elevated levels of leptin, IL-6, and Ox-HDL, increased CEC levels, and decreased EPC and adiponectin levels (all P < 0.01). The Ox-HDL levels were higher in women from Brooklyn versus Huntington (P < 0.01), possibly from higher TNFα levels in Brooklyn or higher adiponectin levels in Huntington. Seventy-five percent of the variance in Ox-HDL levels could be predicted in this population (P < 0.01). CONCLUSIONS: This study reveals a unique inflammatory biomarker profile in females with obesity.
OBJECTIVE: High BMI predicts adverse cardiovascular outcomes and positively correlates with increased levels of adipokines. The relationship among BMI, IL-6, TNFα, adiponectin, and oxidized high-density lipoprotein (Ox-HDL) with circulating endothelial cells (CECs) and endothelial progenitor cells (EPCs) has not been well studied. Elevated CEC levels have been described in both humans and mice with obesity and diabetes. Ox-HDL has been shown to be a potent driver of adipogenesis in vivo and in vitro. In this study, elevated BMI was examined in 2 groups of women studied in Brooklyn, New York, and Huntington, West Virginia, respectively. METHODS: Twenty-six females with obesity and five lean controls without overt cardiovascular disease were enrolled, 13 from Huntington and 13 from Brooklyn. Cytokine levels, EPCs, and CECs were determined. RESULTS: Females with obesity had elevated levels of leptin, IL-6, and Ox-HDL, increased CEC levels, and decreased EPC and adiponectin levels (all P < 0.01). The Ox-HDL levels were higher in women from Brooklyn versus Huntington (P < 0.01), possibly from higher TNFα levels in Brooklyn or higher adiponectin levels in Huntington. Seventy-five percent of the variance in Ox-HDL levels could be predicted in this population (P < 0.01). CONCLUSIONS: This study reveals a unique inflammatory biomarker profile in females with obesity.
Authors: Adam L Kruger; Stephen J Peterson; Michal L Schwartzman; Heidi Fusco; John A McClung; Melvin Weiss; Sylvia Shenouda; Alvin I Goodman; Michael S Goligorsky; Attallah Kappas; Nader G Abraham Journal: J Pharmacol Exp Ther Date: 2006-09-07 Impact factor: 4.030
Authors: Stephen J Peterson; Luca Vanella; Katherine Gotlinger; Houli Jiang; Shailendra P Singh; Komal Sodhi; Eamonn Maher; Kathleen O'Hanlon; Joseph I Shapiro; Nader G Abraham Journal: Prostaglandins Other Lipid Mediat Date: 2016-05-11 Impact factor: 3.072
Authors: Mohamad Navab; Gattadahalli M Anantharamaiah; Srinivasa T Reddy; Brian J Van Lenten; Benjamin J Ansell; Alan M Fogelman Journal: Nat Clin Pract Endocrinol Metab Date: 2006-09
Authors: Jian Cao; Stephen J Peterson; Komal Sodhi; Luca Vanella; Ignazio Barbagallo; Luigi F Rodella; Michal L Schwartzman; Nader G Abraham; Attallah Kappas Journal: Hypertension Date: 2012-07-02 Impact factor: 10.190
Authors: Cheryl L Laffer; Michal Laniado-Schwartzman; Alberto Nasjletti; Fernando Elijovich Journal: Hypertension Date: 2004-01-05 Impact factor: 10.190
Authors: George S Drummond; Jeffrey Baum; Menachem Greenberg; David Lewis; Nader G Abraham Journal: Arch Biochem Biophys Date: 2019-08-16 Impact factor: 4.013
Authors: John A McClung; Lior Levy; Victor Garcia; David E Stec; Stephen J Peterson; Nader G Abraham Journal: Pharmacol Ther Date: 2021-09-06 Impact factor: 12.310
Authors: Lars Bellner; Nachum B Lebovics; Rochelle Rubinstein; Yosef D Buchen; Emilia Sinatra; Giuseppe Sinatra; Nader G Abraham; John A McClung; Ellen A Thompson Journal: Antioxid Redox Signal Date: 2020-02-10 Impact factor: 8.401
Authors: Zeid J Khitan; Imran Khawaja; Maurice A Mufson; Juan R Sanabria; Nader G Abraham; Stephen J Peterson; Uma Sundaram; Joseph I Shapiro Journal: Med Hypotheses Date: 2020-08-10 Impact factor: 1.538
Authors: Shailendra P Singh; John A McClung; Ellen Thompson; Yosef Glick; Menachem Greenberg; Giancarlo Acosta-Baez; Basel Edris; Joseph I Shapiro; Nader G Abraham Journal: Obesity (Silver Spring) Date: 2019-08-23 Impact factor: 5.002
Authors: Marco Raffaele; Maria Licari; Sherif Amin; Ragin Alex; Hsin-Hsueh Shen; Shailendra P Singh; Luca Vanella; Rita Rezzani; Francesca Bonomini; Stephen J Peterson; David E Stec; Nader G Abraham Journal: Int J Mol Sci Date: 2020-07-31 Impact factor: 5.923