| Literature DB >> 30569204 |
Anca Dorhoi1,2,3, Estibaliz Glaría4,5, Thalia Garcia-Tellez6, Natalie E Nieuwenhuizen7, Gennadiy Zelinskyy8, Benoit Favier9, Anurag Singh10, Jan Ehrchen11, Cornelia Gujer12, Christian Münz12, Margarida Saraiva13,14, Yahya Sohrabi15,16, Ana E Sousa17, Peter Delputte18, Michaela Müller-Trutwin6, Annabel F Valledor19,20.
Abstract
Many pathogens, ranging from viruses to multicellular parasites, promote expansion of MDSCs, which are myeloid cells that exhibit immunosuppressive features. The roles of MDSCs in infection depend on the class and virulence mechanisms of the pathogen, the stage of the disease, and the pathology associated with the infection. This work compiles evidence supported by functional assays on the roles of different subsets of MDSCs in acute and chronic infections, including pathogen-associated malignancies, and discusses strategies to modulate MDSC dynamics to benefit the host.Entities:
Keywords: Immunosuppression; Infection; MDSC; Mye-EUNITER; Myeloid regulatory cells; Oncogenic viruses
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Year: 2018 PMID： 30569204 DOI： 10.1007/s00262-018-2277-y
Source DB: PubMed Journal: Cancer Immunol Immunother ISSN： 0340-7004 Impact factor: 6.968