Literature DB >> 30568984

Human Immunodeficiency Virus-1 Drug Resistance Patterns Among Adult Patients Failing Second-Line Protease Inhibitor-Containing Regimens in Namibia, 2010-2015.

Souleymane Sawadogo1, Andreas Shiningavamwe2, Clay Roscoe1, Andrew L Baughman1, Taffa Negussie1, Gram Mutandi1, Chunfu Yang3, Ndapewa Hamunime4, Simon Agolory1.   

Abstract

Three hundred sixty-six adult patients in Namibia with second-line virologic failures were evaluated for human immunodeficiency virus drug-resistant (HIVDR) mutations. Less than half (41.5%) harbored ≥1 HIVDR mutations to standardized second-line antiretroviral therapy (ART) regimen. Optimizing adherence, viral load monitoring, and genotyping are critical to prevent emergence of resistance, as well as unnecessary switching to costly third-line ART regimens.

Entities:  

Keywords:  ART; Namibia; drug resistance; second line

Year:  2018        PMID： 30568984      PMCID： PMC5798139          DOI： 10.1093/ofid/ofy014

Source DB:  PubMed          Journal:  Open Forum Infect Dis        ISSN： 2328-8957            Impact factor:   3.835


  3 in total

1.  Third-line antiretroviral therapy in low-income and middle-income countries (ACTG A5288): a prospective strategy study.

Authors:  Beatriz Grinsztejn; Michael D Hughes; Justin Ritz; Robert Salata; Peter Mugyenyi; Evelyn Hogg; Linda Wieclaw; Robert Gross; Catherine Godfrey; Sandra W Cardoso; Aggrey Bukuru; Mumbi Makanga; Sharlaa Faesen; Vidya Mave; Beatrice Wangari Ndege; Sandy Nerette Fontain; Wadzanai Samaneka; Rode Secours; Marije van Schalkwyk; Rosie Mngqibisa; Lerato Mohapi; Javier Valencia; Patcharaphan Sugandhavesa; Esmelda Montalban; Anchalee Avihingsanon; Breno R Santos; Nagalingeswaran Kumarasamy; Cecilia Kanyama; Robert T Schooley; John W Mellors; Carole L Wallis; Ann C Collier
Journal:  Lancet HIV       Date:  2019-07-29       Impact factor: 12.767

2.  Successful establishment of third-line antiretroviral therapy in Malawi: lessons learned.

Authors:  T Heller; P Ganesh; J Gumulira; L Nkhoma; C Chipingu; C Kanyama; T Kalua; R Nyrienda; S Phiri; A Schooley
Journal:  Public Health Action       Date:  2019-12-21

3.  High levels of HIV drug resistance among adults failing second-line antiretroviral therapy in Namibia.

Authors:  Michael R Jordan; Ndapewa Hamunime; Leonard Bikinesi; Souleymane Sawadogo; Simon Agolory; Andreas N Shiningavamwe; Taffa Negussie; Christa L Fisher-Walker; Elliot G Raizes; Nicholus Mutenda; Christian J Hunter; Natalie Dean; Kim Steegen; Vibha Kana; Sergio Carmona; Chunfu Yang; Alice M Tang; Neil Parkin; Steven Y Hong
Journal:  Medicine (Baltimore)       Date:  2020-09-11       Impact factor: 1.889
  3 in total

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