Literature DB >> 30568974

Rapid Development of High-Level Resistance to Dolutegravir With Emergence of T97A Mutation in 2 Treatment-Experienced Individuals With Baseline Partial Sensitivity to Dolutegravir.

Jomy M George1, Safia S Kuriakose2, Nicola Dee2, Pam Stoll1, Tahaniyat Lalani3, Robin Dewar2, Muhammad A Khan2, Muhammad T Rehman2, Zehava Grossman4,5, Frank Maldarelli4, Alice K Pau6.   

Abstract

HIV integrase mutation T97A emerges after suboptimal therapy with integrase strand transfer inhibitors (INSTIs), but the contribution of T97A to dolutegravir resistance remains uncertain. Here we report >10-fold increase in dolutegravir resistance after the single addition of T97A in 2 individuals with prior INSTI resistance receiving dolutegravir salvage therapy.

Entities:  

Keywords:  T97A; antiretroviral therapy; dolutegravir; drug resistance; salvage therapy

Year:  2018        PMID： 30568974      PMCID： PMC6172925          DOI： 10.1093/ofid/ofy221

Source DB:  PubMed          Journal:  Open Forum Infect Dis        ISSN： 2328-8957            Impact factor:   3.835


  5 in total

1.  A systematic review of the genetic mechanisms of dolutegravir resistance.

Authors:  Soo-Yon Rhee; Philip M Grant; Philip L Tzou; Geoffrey Barrow; P Richard Harrigan; John P A Ioannidis; Robert W Shafer
Journal:  J Antimicrob Chemother       Date:  2019-11-01       Impact factor: 5.790

2.  Antiretroviral Treatment Simplification With 2-Drug Regimens: Impact of Transmitted Drug Resistance Mutations.

Authors:  Harald H Kessler; Evelyn Stelzl; Anja Blažič; Sanjay R Mehta; Anna S Benezeder; Christina Genger-Hackl; Brigitte I Santner; Antoine Chaillon; Martin Hoenigl
Journal:  Open Forum Infect Dis       Date:  2019-12-18       Impact factor: 3.835

3.  Exploring the mechanisms behind HIV drug resistance in sub-Saharan Africa: conceptual mapping of a complex adaptive system based on multi-disciplinary expert insights.

Authors:  Anneleen Kiekens; Bernadette Dierckx de Casterlé; Giampietro Pellizzer; Idda H Mosha; Fausta Mosha; Tobias F Rinke de Wit; Raphael Z Sangeda; Alessio Surian; Nico Vandaele; Liesbet Vranken; Japhet Killewo; Michael Jordan; Anne-Mieke Vandamme
Journal:  BMC Public Health       Date:  2022-03-07       Impact factor: 3.295

4.  Structural basis of second-generation HIV integrase inhibitor action and viral resistance.

Authors:  Nicola J Cook; Wen Li; Dénes Berta; Magd Badaoui; Allison Ballandras-Colas; Andrea Nans; Abhay Kotecha; Edina Rosta; Alan N Engelman; Peter Cherepanov
Journal:  Science       Date:  2020-01-30       Impact factor: 47.728

5.  HIV-1 Subtype C Drug Resistance Mutations in Heavily Treated Patients Failing Integrase Strand Transfer Inhibitor-Based Regimens in Botswana.

Authors:  Kaelo K Seatla; Dorcas Maruapula; Wonderful T Choga; Tshenolo Ntsipe; Nametso Mathiba; Mompati Mogwele; Max Kapanda; Bornapate Nkomo; Dinah Ramaabya; Joseph Makhema; Mompati Mmalane; Madisa Mine; Ishmael Kasvosve; Shahin Lockman; Sikhulile Moyo; Simani Gaseitsiwe
Journal:  Viruses       Date:  2021-03-31       Impact factor: 5.048
  5 in total

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