| Literature DB >> 30567928 |
Arnau Vich Vila1,2, Floris Imhann1,2, Valerie Collij1,2, Soesma A Jankipersadsing2, Thomas Gurry3,4, Zlatan Mujagic5, Alexander Kurilshikov2, Marc Jan Bonder2, Xiaofang Jiang3,4, Ettje F Tigchelaar2, Jackie Dekens2, Vera Peters1, Michiel D Voskuil1,2, Marijn C Visschedijk1,2, Hendrik M van Dullemen1, Daniel Keszthelyi5, Morris A Swertz2, Lude Franke2, Rudi Alberts1,2, Eleonora A M Festen1,2, Gerard Dijkstra1, Ad A M Masclee5, Marten H Hofker6, Ramnik J Xavier3,4, Eric J Alm3,4, Jingyuan Fu2,6, Cisca Wijmenga2, Daisy M A E Jonkers5, Alexandra Zhernakova2, Rinse K Weersma7.
Abstract
Changes in the gut microbiota have been associated with two of the most common gastrointestinal diseases, inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Here, we performed a case-control analysis using shotgun metagenomic sequencing of stool samples from 1792 individuals with IBD and IBS compared with control individuals in the general population. Despite substantial overlap between the gut microbiome of patients with IBD and IBS compared with control individuals, we were able to use gut microbiota composition differences to distinguish patients with IBD from those with IBS. By combining species-level profiles and strain-level profiles with bacterial growth rates, metabolic functions, antibiotic resistance, and virulence factor analyses, we identified key bacterial species that may be involved in two common gastrointestinal diseases.Entities:
Mesh：
Year: 2018 PMID： 30567928 DOI： 10.1126/scitranslmed.aap8914
Source DB: PubMed Journal: Sci Transl Med ISSN： 1946-6234 Impact factor: 17.956