Ujwal Kariholu 1,2 , Paolo Montaldo 1 , Theodora Markati 1,2 , Peter J Lally 1 , Russell Pryce 1,3 , Justinas Teiserskas 2 , Natasha Liow 2 , Vânia Oliveira 1 , Aung Soe 3 , Seetha Shankaran 4 , Sudhin Thayyil 1 Show Affiliations »
Abstract
OBJECTIVES: To examine if therapeutic hypothermia reduces the composite outcome of death, moderate or severe disability at 18 months or more after mild neonatal encephalopathy (NE). DATA SOURCE: MEDLINE, Cochrane database, Scopus and ISI Web of Knowledge databases, using 'hypoxic ischaemic encephalopathy', 'newborn' and 'hypothermia', and 'clinical trials' as medical subject headings and terms. Manual search of the reference lists of all eligible articles and major review articles and additional data from the corresponding authors of selected articles. STUDY SELECTION: Randomised and quasirandomised controlled trials comparing therapeutic hypothermia with usual care. DATA EXTRACTION: Safety and efficacy data extracted independently by two reviewers and analysed. RESULTS: We included the data on 117 babies with mild NE inadvertently recruited to five cooling trials (two whole-body cooling and three selective head cooling) of moderate and severe NE, in the meta-analysis. Adverse outcomes occurred in 11/56 (19.6%) of the cooled babies and 12/61 (19.7%) of the usual care babies (risk ratio 1.11 (95% CIs 0.55 to 2.25)). CONCLUSIONS: Current evidence is insufficient to recommend routine therapeutic hypothermia for babies with mild encephalopathy and significant benefits or harm cannot be excluded. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
OBJECTIVES: To examine if therapeutic hypothermia reduces the composite outcome of death , moderate or severe disability at 18 months or more after mild neonatal encephalopathy (NE). DATA SOURCE: MEDLINE, Cochrane database, Scopus and ISI Web of Knowledge databases, using 'hypoxic ischaemic encephalopathy ', 'newborn' and 'hypothermia' , and 'clinical trials' as medical subject headings and terms. Manual search of the reference lists of all eligible articles and major review articles and additional data from the corresponding authors of selected articles. STUDY SELECTION: Randomised and quasirandomised controlled trials comparing therapeutic hypothermia with usual care. DATA EXTRACTION: Safety and efficacy data extracted independently by two reviewers and analysed. RESULTS: We included the data on 117 babies with mild NE inadvertently recruited to five cooling trials (two whole-body cooling and three selective head cooling) of moderate and severe NE, in the meta-analysis. Adverse outcomes occurred in 11/56 (19.6%) of the cooled babies and 12/61 (19.7%) of the usual care babies (risk ratio 1.11 (95% CIs 0.55 to 2.25)). CONCLUSIONS: Current evidence is insufficient to recommend routine therapeutic hypothermia for babies with mild encephalopathy and significant benefits or harm cannot be excluded. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Entities: Disease
Keywords:
hypoxic ischaemic encephalopathy; meta-analysis; newborn; therapeutic hypothermia
Mesh： See more »
Year: 2018
PMID： 30567775 DOI： 10.1136/archdischild-2018-315711
Source DB: PubMed Journal: Arch Dis Child Fetal Neonatal Ed ISSN： 1359-2998 Impact factor: 5.747