Farida Benhadou1,2, Dillon Mintoff3, Véronique Del Marmol4. 1. Dermatology Department, Erasme Hospital, Université Libre de Bruxelles - ULB, Brussels, Belgium, farida.benhadou@erasme.ulb.ac.be. 2. Laboratory of Stem Cells and Cancer, Unversité Libre de Bruxelles - ULB, Brussels, Belgium, farida.benhadou@erasme.ulb.ac.be. 3. Dermatology Department, Sir Paul Boffa Hospital, Floriana, Malta. 4. Dermatology Department, Erasme Hospital, Université Libre de Bruxelles - ULB, Brussels, Belgium.
Abstract
BACKGROUND: Psoriasis is a common, chronic inflammatory skin disorder, which can significantly impact quality of life. Despite major breakthroughs in our understanding of the pathogenesis of psoriasis, the chronological order of the underlying mechanisms leading to the development of psoriatic plaques remains to be completely understood. SUMMARY: Although psoriasis is classically perceived as a T-cell disease, it is now well recognized that T lymphocytes do not function in exclusivity. This theory is supported by evidence from transgenic murine models that develop marked psoriasiform disease. In addition, immune cells and cytokines regulate both early and late events involved in the pathogenesis of psoriasis. Key Messages: Psoriasis is a complex disease - a dynamic interplay between immune cells, keratinocytes, and various other skin-resident cells, such as endothelial and immune cells. The contribution of each cell type is crucial in the initiation and maintenance phases of psoriatic alterations.
BACKGROUND:Psoriasis is a common, chronic inflammatory skin disorder, which can significantly impact quality of life. Despite major breakthroughs in our understanding of the pathogenesis of psoriasis, the chronological order of the underlying mechanisms leading to the development of psoriatic plaques remains to be completely understood. SUMMARY: Although psoriasis is classically perceived as a T-cell disease, it is now well recognized that T lymphocytes do not function in exclusivity. This theory is supported by evidence from transgenic murine models that develop marked psoriasiform disease. In addition, immune cells and cytokines regulate both early and late events involved in the pathogenesis of psoriasis. Key Messages: Psoriasis is a complex disease - a dynamic interplay between immune cells, keratinocytes, and various other skin-resident cells, such as endothelial and immune cells. The contribution of each cell type is crucial in the initiation and maintenance phases of psoriatic alterations.
Authors: Rinkesh K Gupta; Donald T Gracias; Daniela Salgado Figueroa; Haruka Miki; Jacqueline Miller; Kai Fung; Ferhat Ay; Linda Burkly; Michael Croft Journal: Sci Immunol Date: 2021-11-19
Authors: Mi Ran Choi; Hae Dong Kim; Sinyoung Cho; Seong Ho Jeon; Dong Hyun Kim; Jungwon Wee; Young Duk Yang Journal: Int J Mol Sci Date: 2021-07-01 Impact factor: 5.923