Literature DB >> 30566366

The Antibody Response to Plasmodium falciparum: Cues for Vaccine Design and the Discovery of Receptor-Based Antibodies.

Joshua Tan1,2,3, Luca Piccoli1, Antonio Lanzavecchia1,4.   

Abstract

Plasmodium falciparum remains a serious public health problem and a continuous challenge for the immune system due to the complexity and diversity of the pathogen. Recent advances from several laboratories in the characterization of the antibody response to the parasite have led to the identification of critical targets for protection and revealed a new mechanism of diversification based on the insertion of host receptors into immunoglobulin genes, leading to the production of receptor-based antibodies. These advances have opened new possibilities for vaccine design and passive antibody therapies to provide sterilizing immunity and control blood-stage parasites.

Entities:  

Keywords:  antibody diversification; malaria; monoclonal antibodies; receptor-based antibodies; sporozoites; vaccines

Mesh：

Substances：

Year:  2018        PMID： 30566366     DOI： 10.1146/annurev-immunol-042617-053301

Source DB:  PubMed          Journal:  Annu Rev Immunol        ISSN： 0732-0582            Impact factor:   28.527


  10 in total

Review 1.  Subdominance in Antibody Responses: Implications for Vaccine Development.

Authors:  Gunnar Lindahl
Journal:  Microbiol Mol Biol Rev       Date:  2020-11-25       Impact factor: 11.056

2.  The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria.

Authors:  Lawrence T Wang; Nicholas K Hurlburt; Arne Schön; Barbara J Flynn; Yevel Flores-Garcia; Lais S Pereira; Patience K Kiyuka; Marlon Dillon; Brian Bonilla; Fidel Zavala; Azza H Idris; Joseph R Francica; Marie Pancera; Robert A Seder
Journal:  Cell Rep       Date:  2022-02-15       Impact factor: 9.423

3.  Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies.

Authors:  Sven Kratochvil; Chen-Hsiang Shen; Ying-Cing Lin; Kai Xu; Usha Nair; Lais Da Silva Pereira; Prabhanshu Tripathi; Johan Arnold; Gwo-Yu Chuang; Eleonora Melzi; Arne Schön; Baoshan Zhang; Marlon Dillon; Brian Bonilla; Barbara J Flynn; Kathrin H Kirsch; Neville K Kisalu; Patience K Kiyuka; Tracy Liu; Li Ou; Marie Pancera; Reda Rawi; Mateo Reveiz; Kareen Seignon; Lawrence T Wang; Michael T Waring; John Warner; Yongping Yang; Joseph R Francica; Azza H Idris; Robert A Seder; Peter D Kwong; Facundo D Batista
Journal:  Immunity       Date:  2021-11-16       Impact factor: 43.474

Review 4.  Human unconventional T cells in Plasmodium falciparum infection.

Authors:  Mathias Schmaler; Nina Orlova-Fink; Tobias Rutishauser; Salim Abdulla; Claudia Daubenberger
Journal:  Semin Immunopathol       Date:  2020-02-19       Impact factor: 9.623

5.  Breadth of Antibodies to Plasmodium falciparum Variant Surface Antigens Is Associated With Immunity in a Controlled Human Malaria Infection Study.

Authors:  Hannah W Kimingi; Ann W Kinyua; Nicole A Achieng; Kennedy M Wambui; Shaban Mwangi; Roselyne Nguti; Cheryl A Kivisi; Anja T R Jensen; Philip Bejon; Melisa C Kapulu; Abdirahman I Abdi; Samson M Kinyanjui
Journal:  Front Immunol       Date:  2022-05-30       Impact factor: 8.786

Review 6.  Antibodies against Plasmodium falciparum malaria at the molecular level.

Authors:  Jean-Philippe Julien; Hedda Wardemann
Journal:  Nat Rev Immunol       Date:  2019-08-28       Impact factor: 53.106

Review 7.  Quantum leap of monoclonal antibody (mAb) discovery and development in the COVID-19 era.

Authors:  Simone Pecetta; Oretta Finco; Anja Seubert
Journal:  Semin Immunol       Date:  2020-11-17       Impact factor: 11.130

Review 8.  Five decades of clinical assessment of whole-sporozoite malaria vaccines.

Authors:  Helena Nunes-Cabaço; Diana Moita; Miguel Prudêncio
Journal:  Front Immunol       Date:  2022-09-08       Impact factor: 8.786

9.  Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model.

Authors:  Nicholas J Tursi; Sophia M Reeder; Yevel Flores-Garcia; Mamadou A Bah; Shamika Mathis-Torres; Berenice Salgado-Jimenez; Rianne Esquivel; Ziyang Xu; Jacqueline D Chu; Laurent Humeau; Ami Patel; Fidel Zavala; David B Weiner
Journal:  Sci Rep       Date:  2022-08-22       Impact factor: 4.996

10.  Functional human IgA targets a conserved site on malaria sporozoites.

Authors:  Joshua Tan; Hyeseon Cho; Tossapol Pholcharee; Lais S Pereira; Safiatou Doumbo; Didier Doumtabe; Barbara J Flynn; Arne Schön; Sachie Kanatani; Samantha O Aylor; David Oyen; Rachel Vistein; Lawrence Wang; Marlon Dillon; Jeff Skinner; Mary Peterson; Shanping Li; Azza H Idris; Alvaro Molina-Cruz; Ming Zhao; Lisa Renee Olano; Patricia J Lee; Alison Roth; Photini Sinnis; Carolina Barillas-Mury; Kassoum Kayentao; Aissata Ongoiba; Joseph R Francica; Boubacar Traore; Ian A Wilson; Robert A Seder; Peter D Crompton
Journal:  Sci Transl Med       Date:  2021-06-23       Impact factor: 17.956
  10 in total

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