| Literature DB >> 30565922 |
Yoav Atsmon-Raz1,2, Vered Wineman-Fisher3, Michal Baram1,2, Yifat Miller1,2.
Abstract
Orientational inversion events of residues along the turn domains of amylin fibrils have been detected. This exceptional phenomenon has been observed in isolated amylin fibrils and in the cross-seeding amylin-Aβ and amylin-NAC fibrils. These new findings provide new avenues for detection of side chain flipping and side chain inversion events in turn domains and loops of various proteins.Entities:
Keywords: Amyloid; peptide-plane in proteins; polymorphism; self-assembly; structural interconversion
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Year: 2018 PMID： 30565922 DOI： 10.1021/acschemneuro.8b00554
Source DB: PubMed Journal: ACS Chem Neurosci ISSN： 1948-7193 Impact factor: 4.418