James Orsborne1, Luis Furuya-Kanamori2, Claire L Jeffries1, Mojca Kristan1, Abdul Rahim Mohammed3, Yaw A Afrane3, Kathleen O'Reilly1, Eduardo Massad4, Chris Drakeley5, Thomas Walker1, Laith Yakob6. 1. Department of Disease Control, London School of Hygiene & Tropical Medicine, London, UK. 2. Department of Population Medicine, College of Medicine, Qatar University, Doha, Qatar. 3. Department of Medical Microbiology, College of Health Sciences, University of Ghana, Korle Bu, Accra, Ghana. 4. School of Applied Mathematics, Fundacao Getulio Vargas, Rio de Janeiro, Brazil. 5. Department of Immunology & Infection, London School of Hygiene & Tropical Medicine, London, UK. 6. Department of Disease Control, London School of Hygiene & Tropical Medicine, London, UK. Laith.yakob@lshtm.ac.uk.
Abstract
BACKGROUND: The proportion of mosquito blood-meals that are of human origin, referred to as the 'human blood index' or HBI, is a key determinant of malaria transmission. METHODS: A systematic review was conducted followed by meta-regression of the HBI for the major African malaria vectors. RESULTS: Evidence is presented for higher HBI among Anopheles gambiae (M/S forms and Anopheles coluzzii/An. gambiae sensu stricto are not distinguished for most studies and, therefore, combined) as well as Anopheles funestus when compared with Anopheles arabiensis (prevalence odds ratio adjusted for collection location [i.e. indoor or outdoor]: 1.62; 95% CI 1.09-2.42; 1.84; 95% CI 1.35-2.52, respectively). This finding is in keeping with the entomological literature which describes An. arabiensis to be more zoophagic than the other major African vectors. However, analysis also revealed that HBI was more associated with location of mosquito captures (R2 = 0.29) than with mosquito (sibling) species (R2 = 0.11). CONCLUSIONS: These findings call into question the appropriateness of current methods of assessing host preferences among disease vectors and have important implications for strategizing vector control.
BACKGROUND: The proportion of mosquito blood-meals that are of human origin, referred to as the 'humanblood index' or HBI, is a key determinant of malaria transmission. METHODS: A systematic review was conducted followed by meta-regression of the HBI for the major African malaria vectors. RESULTS: Evidence is presented for higher HBI among Anopheles gambiae (M/S forms and Anopheles coluzzii/An. gambiae sensu stricto are not distinguished for most studies and, therefore, combined) as well as Anopheles funestus when compared with Anopheles arabiensis (prevalence odds ratio adjusted for collection location [i.e. indoor or outdoor]: 1.62; 95% CI 1.09-2.42; 1.84; 95% CI 1.35-2.52, respectively). This finding is in keeping with the entomological literature which describes An. arabiensis to be more zoophagic than the other major African vectors. However, analysis also revealed that HBI was more associated with location of mosquito captures (R2 = 0.29) than with mosquito (sibling) species (R2 = 0.11). CONCLUSIONS: These findings call into question the appropriateness of current methods of assessing host preferences among disease vectors and have important implications for strategizing vector control.
Authors: Jan J Barendregt; Suhail A Doi; Yong Yi Lee; Rosana E Norman; Theo Vos Journal: J Epidemiol Community Health Date: 2013-08-20 Impact factor: 3.710
Authors: Thierry Lefèvre; Louis-Clément Gouagna; Kounbrobr Roch Dabiré; Eric Elguero; Didier Fontenille; François Renaud; Carlo Costantini; Frédéric Thomas Journal: Am J Trop Med Hyg Date: 2009-12 Impact factor: 2.345
Authors: S Bhatt; D J Weiss; E Cameron; D Bisanzio; B Mappin; U Dalrymple; K Battle; C L Moyes; A Henry; P A Eckhoff; E A Wenger; O Briët; M A Penny; T A Smith; A Bennett; J Yukich; T P Eisele; J T Griffin; C A Fergus; M Lynch; F Lindgren; J M Cohen; C L J Murray; D L Smith; S I Hay; R E Cibulskis; P W Gething Journal: Nature Date: 2015-09-16 Impact factor: 49.962
Authors: James Orsborne; Abdul Rahim Mohammed; Claire L Jeffries; Mojca Kristan; Yaw A Afrane; Thomas Walker; Laith Yakob Journal: Sci Rep Date: 2020-01-20 Impact factor: 4.379
Authors: Sandra Sayuri Nagaki; Leonardo S M Chaves; Rossana Verónica Mendoza López; Eduardo S Bergo; Gabriel Z Laporta; Jan E Conn; Maria Anice Mureb Sallum Journal: Acta Trop Date: 2020-11-06 Impact factor: 3.112
Authors: Micaela Finney; Benjamin A McKenzie; Bernadette Rabaovola; Alice Sutcliffe; Ellen Dotson; Sarah Zohdy Journal: Malar J Date: 2021-01-07 Impact factor: 2.979
Authors: Sulaiman S Ibrahim; Muhammad M Mukhtar; Helen Irving; Jacob M Riveron; Amen N Fadel; Williams Tchapga; Jack Hearn; Abdullahi Muhammad; Faruk Sarkinfada; Charles S Wondji Journal: Genes (Basel) Date: 2020-04-22 Impact factor: 4.096