Literature DB >> 3056346

Microencapsulated hepatocytes for bioartificial liver support.

Z H Cai1, Z Q Shi, G M O'Shea, A M Sun.   

Abstract

Free hepatocytes, harvested from normal rat livers by portal vein collagenase perfusion, were encapsulated within alginate-polylysine membranes and served as a liver support system. The encapsulated hepatocytes remained viable and were able to synthesize protein for up to 3 weeks in culture. Allografts of encapsulated hepatocytes replaced the function of a damaged liver and reduced the mortality rate among rats with galactosamine-induced fulminant hepatic failure.

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Year:  1988        PMID： 3056346     DOI： 10.1111/j.1525-1594.1988.tb02793.x

Source DB:  PubMed          Journal:  Artif Organs        ISSN： 0160-564X            Impact factor:   3.094


  8 in total

1.  Microgravity as a means to incorporate HepG2 aggregates in polysaccharide-protein hybrid scaffold.

Authors:  P R Sarika; Nirmala Rachel James; P R Anilkumar; Deepa K Raj; T V Kumary
Journal:  J Mater Sci Mater Med       Date:  2015-12-24       Impact factor: 3.896

2.  Fabrication and characterization of chitosan microcarrier for hepatocyte culture.

Authors:  Chen Wu; Jilun Pan; Zhiming Bao; Yaoting Yu
Journal:  J Mater Sci Mater Med       Date:  2007-08-01       Impact factor: 3.896

3.  Internal bioartificial liver with xenogeneic hepatocytes prevents death from acute liver failure: an experimental study.

Authors:  V Roger; P Balladur; J Honiger; M Baudrimont; R Delelo; A Robert; Y Calmus; J Capeau; B Nordlinger
Journal:  Ann Surg       Date:  1998-07       Impact factor: 12.969

Review 4.  Generating intestinal tissue from stem cells: potential for research and therapy.

Authors:  Jonathan C Howell; James M Wells
Journal:  Regen Med       Date:  2011-11       Impact factor: 3.806

Review 5.  Artificial livers--what's keeping them?

Authors:  E Davies; H J Hodgson
Journal:  Gut       Date:  1995-02       Impact factor: 23.059

6.  Production of purified alginates suitable for use in immunoisolated transplantation.

Authors:  G Klöck; H Frank; R Houben; T Zekorn; A Horcher; U Siebers; M Wöhrle; K Federlin; U Zimmermann
Journal:  Appl Microbiol Biotechnol       Date:  1994-01       Impact factor: 4.813

7.  Primary culture of rat hepatocytes entrapped in cylindrical collagen gels: an in vitro system with application to the bioartificial liver. Rat hepatocytes cultured in cylindrical collagen gels.

Authors:  S L Nyberg; R A Shatford; W D Payne; W S Hu; F B Cerra
Journal:  Cytotechnology       Date:  1992       Impact factor: 2.058

8.  Evaluation of encapsulated liver cell spheroids in a fluidised-bed bioartificial liver for treatment of ischaemic acute liver failure in pigs in a translational setting.

Authors:  Clare Selden; Catherine Wendy Spearman; Delawir Kahn; Malcolm Miller; Anthony Figaji; Eloy Erro; James Bundy; Isobel Massie; Sherri-Ann Chalmers; Hiram Arendse; Aude Gautier; Peter Sharratt; Barry Fuller; Humphrey Hodgson
Journal:  PLoS One       Date:  2013-12-18       Impact factor: 3.240
  8 in total

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