Literature DB >> 3056241

Structure-activity relationships of selected phenazines against Mycobacterium leprae in vitro.

S G Franzblau1, J F O'Sullivan.   

Abstract

Structure-activity relationships of phenazines against Mycobacterium leprae were investigated by using an in vitro radiorespirometric assay. In general, activity in ascending order was observed in compounds containing no chlorine atoms, a monochlorinated phenazine nucleus, and chlorines in the para positions of both the anilino and phenyl rings. The most active compounds contained a 2,2,6,6-tetramethylpiperidine substitution at the imino nitrogen. Most of these chlorinated phenazines were considerably more active in vitro than clofazimine (B663).

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Year:  1988        PMID： 3056241      PMCID： PMC175923          DOI： 10.1128/AAC.32.10.1583

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  "B 663" in the treatment of leprosy. Preliminary report of a pilot trial.

Authors:  S G BROWNE; L M HOGERZEIL
Journal:  Lepr Rev       Date:  1962-01       Impact factor: 0.537

2.  A treatment of corticosteroid-dependent lepromatous patients in persistent erythema nodosum leprosum. A clinical evaluation of G.30320 (B663).

Authors:  F M Imkamp
Journal:  Lepr Rev       Date:  1968-07       Impact factor: 0.537

3.  Rapid, radiometric in vitro assay for the evaluation of the anti-leprosy activity of clofazimine and its analogues.

Authors:  A Mittal; P S Seshadri; M L Conalty; J F O'Sullivan; I Nath
Journal:  Lepr Rev       Date:  1985-06       Impact factor: 0.537

Review 4.  Chemotherapy of leprosy.

Authors:  R C Hastings; S G Franzblau
Journal:  Annu Rev Pharmacol Toxicol       Date:  1988       Impact factor: 13.820

5.  Antituberculosis activity in the phenazine series. II. N3-substituted anilinoaposafranines (rimino-compounds) and some derivatives.

Authors:  V C BARRY; M L CONALTY
Journal:  Am Rev Tuberc       Date:  1958-07

6.  Rapid in vitro metabolic screen for antileprosy compounds.

Authors:  S G Franzblau; R C Hastings
Journal:  Antimicrob Agents Chemother       Date:  1987-05       Impact factor: 5.191

7.  Measurement of hypoxanthine incorporation in purified suspensions of Mycobacterium leprae: a suitable method to screen for anti-leprosy agents in vitro.

Authors:  P R Wheeler
Journal:  J Med Microbiol       Date:  1988-03       Impact factor: 2.472

8.  Clofazimine analogues active against a clofazimine-resistant organism.

Authors:  J F O'Sullivan; M L Conalty; N E Morrison
Journal:  J Med Chem       Date:  1988-03       Impact factor: 7.446

9.  Evaluation of the BACTEC radiometric method for recovery of mycobacteria and drug susceptibility testing of Mycobacterium tuberculosis from acid-fast smear-positive specimens.

Authors:  G D Roberts; N L Goodman; L Heifets; H W Larsh; T H Lindner; J K McClatchy; M R McGinnis; S H Siddiqi; P Wright
Journal:  J Clin Microbiol       Date:  1983-09       Impact factor: 5.948

Review 10.  Lamprene (clofazimine) in leprosy. Basic information.

Authors:  S J Yawalkar; W Vischer
Journal:  Lepr Rev       Date:  1979-06       Impact factor: 0.537
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  9 in total

1.  Fusidic acid is highly active against extracellular and intracellular Mycobacterium leprae.

Authors:  S G Franzblau; A N Biswas; E B Harris
Journal:  Antimicrob Agents Chemother       Date:  1992-01       Impact factor: 5.191

2.  Apoptosis-inducing activity of clofazimine in macrophages.

Authors:  Yasuo Fukutomi; Yumi Maeda; Masahiko Makino
Journal:  Antimicrob Agents Chemother       Date:  2011-06-20       Impact factor: 5.191

3.  Mycobacterium leprae is naturally resistant to PA-824.

Authors:  Ujjini H Manjunatha; Ramanuj Lahiri; Baljit Randhawa; Cynthia S Dowd; James L Krahenbuhl; Clifton E Barry
Journal:  Antimicrob Agents Chemother       Date:  2006-10       Impact factor: 5.191

4.  Comparative in vitro activities of 20 fluoroquinolones against Mycobacterium leprae.

Authors:  S G Franzblau; K E White
Journal:  Antimicrob Agents Chemother       Date:  1990-02       Impact factor: 5.191

5.  In vitro activities of aminoglycosides, lincosamides, and rifamycins against Mycobacterium leprae.

Authors:  S G Franzblau
Journal:  Antimicrob Agents Chemother       Date:  1991-06       Impact factor: 5.191

6.  Structure-activity relationships of tetramethylpiperidine-substituted phenazines against Mycobacterium leprae in vitro.

Authors:  S G Franzblau; K E White; J F O'Sullivan
Journal:  Antimicrob Agents Chemother       Date:  1989-11       Impact factor: 5.191

7.  Drug susceptibility testing of Mycobacterium leprae in the BACTEC 460 system.

Authors:  S G Franzblau
Journal:  Antimicrob Agents Chemother       Date:  1989-12       Impact factor: 5.191

8.  In vitro investigation of clofazimine analogues for antiplasmodial, cytotoxic and pro-oxidative activities.

Authors:  E M Makgatho; E F Mbajiorgu
Journal:  Afr Health Sci       Date:  2017-03       Impact factor: 0.927

Review 9.  Activity of Riminophenazines against Mycobacterium tuberculosis: A Review of Studies that Might be Contenders for Use as Antituberculosis Agents.

Authors:  Mpelegeng Victoria Bvumbi
Journal:  ChemMedChem       Date:  2020-10-15       Impact factor: 3.540
  9 in total

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