Raja Dandamudi1, Jodi Smith2, Vikas R Dharnidharka1. 1. Division of Pediatric Nephrology, Hypertension and Pheresis, Washington University School of Medicine and St Louis Children's Hospital, St. Louis. 2. Division of Pediatric Nephrology, University of Washington and Seattle Children's Hospital, Seattle, USA.
Abstract
PURPOSE OF REVIEW: Infections represent a significant source of morbidity and mortality after kidney transplantation in children. We review recent advances in epidemiology, assessment, prevention and treatment for several different infections. RECENT FINDINGS: Infections, such as bacterial urinary tract infection or opportunistic viral infection remain common, may be increasing and represent a large proportion of hospitalization. Extended antiviral agent use reduces the incidence of cytomegalovirus disease but its efficacy to reduce Epstein-Barr virus disease remains controversial. Human herpesvirus-6 and hepatitis E virus represent new infections to keep in mind. Ureteral stenting increases the rate of early UTI. Several new vaccines are now available, but rates of complete vaccination pretransplant are low. SUMMARY: Infections remain a critical posttransplant issue associated with significant medical burdens. Emerging data on associated risk factors, assessment of and treatment for infections provide clinicians with new knowledge.
PURPOSE OF REVIEW: Infections represent a significant source of morbidity and mortality after kidney transplantation in children. We review recent advances in epidemiology, assessment, prevention and treatment for several different infections. RECENT FINDINGS:Infections, such as bacterial urinary tract infection or opportunistic viral infection remain common, may be increasing and represent a large proportion of hospitalization. Extended antiviral agent use reduces the incidence of cytomegalovirus disease but its efficacy to reduce Epstein-Barr virus disease remains controversial. Human herpesvirus-6 and hepatitis E virus represent new infections to keep in mind. Ureteral stenting increases the rate of early UTI. Several new vaccines are now available, but rates of complete vaccination pretransplant are low. SUMMARY:Infections remain a critical posttransplant issue associated with significant medical burdens. Emerging data on associated risk factors, assessment of and treatment for infections provide clinicians with new knowledge.
Authors: Jéssica Vasques Raposo; Arthur Daniel Rocha Alves; Alexandre Dos Santos da Silva; Damião Carlos Dos Santos; Juliana Gil Melgaço; Otacílio C Moreira; Marcelo Alves Pinto; Vanessa Salete de Paula Journal: BMC Infect Dis Date: 2019-09-04 Impact factor: 3.090
Authors: Thaís Lira Cleto-Yamane; Gustavo Rodrigues-Santos; Maria Clara de Magalhães-Barbosa; Patrícia Gomes Moura; Rafael Dias Vasconcelos; Jaqueline Leal Santos Gouveia; Anne Louise de Oliveira; Fernanda Couto Ferreira; Ana Letícia Shalders; Mariana Barros Genuíno de Oliveira; Fernanda Lima-Setta; Antonio José Ledo Alves da Cunha; Arnaldo Prata-Barbosa Journal: Eur J Pediatr Date: 2021-03-26 Impact factor: 3.183