Nicole M Armstrong1, Jennifer A Deal2,3, Joshua Betz3,4, Stephen Kritchevsky5, Sheila Pratt6,7, Tamara Harris1, Lisa C Barry8, Eleanor M Simonsick1, Frank R Lin2,4,9,10. 1. National Institute on Aging Intramural Research Program, Baltimore, Maryland. 2. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. 3. Division of Geriatric Medicine and Gerontology, Center on Aging and Health, Johns Hopkins University School of Medicine, Baltimore, Maryland. 4. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. 5. Gerontology and Geriatric Medicine Center on Diabetes, Obesity, and Metabolism, Wake Forest School of Medicine, Winston-Salem, North Carolina. 6. School of Health and Rehabilitation Sciences, University of Pittsburgh, Pennsylvania. 7. Geriatric Research and Clinical Education Center, VA Pittsburgh Healthcare System, Pennsylvania. 8. Center on Aging, University of Connecticut Health Center, Farmington. 9. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. 10. Department of Otolaryngology-Head & Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Abstract
BACKGROUND: Depressive symptoms and hearing loss (HL) are independently associated with increased risk of incident disability; whether the increased risk is additive is unclear. METHODS: Cox Proportional Hazards models were used to assess joint associations of HL (normal, mild, moderate/severe) and late-life depressive symptoms (defined by a score of ≥8 on the 10-item Center for Epidemiologic Studies-Depression scale) with onset of mobility disability (a lot of difficulty or inability to walk ¼ mile and/or climb 10 steps) and any disability in activities of daily living (ADL), among 2,196 participants of the Health, Aging and Body Composition Study, a cohort of well-functioning older adults aged 70-79 years. Models were adjusted for age, race, sex, education, diabetes, hypertension, and body mass index. RESULTS: Relative to participants with normal hearing and without depressive symptoms, participants without depressive symptoms who had mild or moderate/severe HL had increased risk of incident mobility and ADL disability (hazard ratio [HR] for mobility disability, mild HL:1.34, 95% confidence interval [CI]: 1.09, 1.64 and HR for mobility disability, moderate/severe HL: 1.37, 95% CI: 1.08, 1.75 and HR for ADL disability, mild HL: 1.32, 95% CI: 1.08, 1.63, and HR for ADL disability, moderate/severe HL: 1.42, 95% CI: 1.11, 1.82). Among participants with depressive symptoms, mild HL (HR: 1.71, 95% CI: 1.09, 2.70) was associated with increased risk of incident mobility disability. CONCLUSIONS: Independent of depressive symptoms, risk of incident disability was greater in older adults with HL, regardless of severity. Further research into HL interventions may delay disability onset. Published by Oxford University Press on behalf of The Gerontological Society of America 2018.
BACKGROUND:Depressive symptoms and hearing loss (HL) are independently associated with increased risk of incident disability; whether the increased risk is additive is unclear. METHODS: Cox Proportional Hazards models were used to assess joint associations of HL (normal, mild, moderate/severe) and late-life depressive symptoms (defined by a score of ≥8 on the 10-item Center for Epidemiologic Studies-Depression scale) with onset of mobility disability (a lot of difficulty or inability to walk ¼ mile and/or climb 10 steps) and any disability in activities of daily living (ADL), among 2,196 participants of the Health, Aging and Body Composition Study, a cohort of well-functioning older adults aged 70-79 years. Models were adjusted for age, race, sex, education, diabetes, hypertension, and body mass index. RESULTS: Relative to participants with normal hearing and without depressive symptoms, participants without depressive symptoms who had mild or moderate/severe HL had increased risk of incident mobility and ADL disability (hazard ratio [HR] for mobility disability, mild HL:1.34, 95% confidence interval [CI]: 1.09, 1.64 and HR for mobility disability, moderate/severe HL: 1.37, 95% CI: 1.08, 1.75 and HR for ADL disability, mild HL: 1.32, 95% CI: 1.08, 1.63, and HR for ADL disability, moderate/severe HL: 1.42, 95% CI: 1.11, 1.82). Among participants with depressive symptoms, mild HL (HR: 1.71, 95% CI: 1.09, 2.70) was associated with increased risk of incident mobility disability. CONCLUSIONS: Independent of depressive symptoms, risk of incident disability was greater in older adults with HL, regardless of severity. Further research into HL interventions may delay disability onset. Published by Oxford University Press on behalf of The Gerontological Society of America 2018.
Authors: Nicole M Armstrong; Camila Vieira Ligo Teixeira; Colby Gendron; Willa D Brenowitz; Frank R Lin; Bonnelin Swenor; Jennifer A Deal; Eleanor M Simonsick; Richard N Jones Journal: J Am Geriatr Soc Date: 2022-03-28 Impact factor: 7.538
Authors: Pauline H Croll; Elisabeth J Vinke; Nicole M Armstrong; Silvan Licher; Meike W Vernooij; Robert J Baatenburg de Jong; André Goedegebure; M Arfan Ikram Journal: J Neurol Date: 2020-09-10 Impact factor: 4.849