Hongbing Mei1, Yuhan Liu1, Qun Zhou1,2, Kun Hu1,2, Yuchen Liu1. 1. Department of Urology, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518000, PR China. 2. Department of Urology, Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen 518000, Guangdong, PR China.
Abstract
AIM: it has been reported that metastasis-associated lung adenocarcinoma transcript 1 is abnormally expressed in various cancers. METHODS: eligible studies fulfilling the search criteria were selected from the online databases. Statistical analysis was performed based on the platforms of STATA 14.0. RESULTS: 12 studies were included in this study comprising 741 cases and 794 controls. The pooled results were shown as follows: sensitivity, 0.74 (95% CI: 0.64-0.82), specificity, 0.83 (95% CI: 0.75-0.88), positive likelihood ratio (PLR), 4.2 (95% CI: 3.00-5.90), negative likelihood, 0.32 (95% CI: 0.23-0.43), diagnostic odds ratio, 13 (95%CI: 8.00-21.00) and area under the curve, 0.85 (95%CI: 0.82-0.88). Deeks' funnel plot asymmetry test (p = 0.70) suggested no potential publication bias. CONCLUSION: long noncoding RNA Metastasis-associated lung adenocarcinoma transcript 1 might be a usable biomarker for cancer diagnosis and detection.
AIM: it has been reported that metastasis-associated lung adenocarcinoma transcript 1 is abnormally expressed in various cancers. METHODS: eligible studies fulfilling the search criteria were selected from the online databases. Statistical analysis was performed based on the platforms of STATA 14.0. RESULTS: 12 studies were included in this study comprising 741 cases and 794 controls. The pooled results were shown as follows: sensitivity, 0.74 (95% CI: 0.64-0.82), specificity, 0.83 (95% CI: 0.75-0.88), positive likelihood ratio (PLR), 4.2 (95% CI: 3.00-5.90), negative likelihood, 0.32 (95% CI: 0.23-0.43), diagnostic odds ratio, 13 (95%CI: 8.00-21.00) and area under the curve, 0.85 (95%CI: 0.82-0.88). Deeks' funnel plot asymmetry test (p = 0.70) suggested no potential publication bias. CONCLUSION: long noncoding RNA Metastasis-associated lung adenocarcinoma transcript 1 might be a usable biomarker for cancer diagnosis and detection.
Entities:
Keywords:
cancer; diagnosis; long noncoding RNA MALAT1; meta-analysis; prognosis