Nicholas R Lenze1, Douglas R Farquhar1, Angela L Mazul2, Maheer M Masood1, Jose P Zevallos3. 1. Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina. 2. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina. 3. Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Abstract
BACKGROUND: This study used a meta-analysis to quantify the degree to which the racial disparity in overall survival for black versus white Americans with oropharyngeal squamous cell carcinoma (OPSCC) persists after adjusting for human papillomavirus (HPV) status. METHODS: PubMed/MEDLINE, Cochrane Database of Systematic Reviews, and CINAHLA were searched through November 2017. The PRISMA statement was followed. The pooled hazard ratio (HR) was calculated using a random-effects model. RESULTS: Five studies met the inclusion criteria and had suitable data for pooling into the meta-analysis (N = 1153). The pooled HR for overall survival in black versus white Americans with OPSCC after adjusting for HPV status was calculated to be 1.45 (95% confidence interval, 0.87-2.40). CONCLUSIONS: The difference in survival for black versus white Americans with OPSCC is not significant after adjusting for HPV status but still trends in the direction of a disparity. Additional studies are needed to better characterize this disparity.
BACKGROUND: This study used a meta-analysis to quantify the degree to which the racial disparity in overall survival for black versus white Americans with oropharyngeal squamous cell carcinoma (OPSCC) persists after adjusting for human papillomavirus (HPV) status. METHODS: PubMed/MEDLINE, Cochrane Database of Systematic Reviews, and CINAHLA were searched through November 2017. The PRISMA statement was followed. The pooled hazard ratio (HR) was calculated using a random-effects model. RESULTS: Five studies met the inclusion criteria and had suitable data for pooling into the meta-analysis (N = 1153). The pooled HR for overall survival in black versus white Americans with OPSCC after adjusting for HPV status was calculated to be 1.45 (95% confidence interval, 0.87-2.40). CONCLUSIONS: The difference in survival for black versus white Americans with OPSCC is not significant after adjusting for HPV status but still trends in the direction of a disparity. Additional studies are needed to better characterize this disparity.
Authors: Nicholas R Lenze; Douglas Farquhar; Siddharth Sheth; Jose P Zevallos; Jeffrey Blumberg; Catherine Lumley; Samip Patel; Trevor Hackman; Mark C Weissler; Wendell G Yarbrough; Adam M Zanation; Andrew F Olshan Journal: Laryngoscope Date: 2020-11-10 Impact factor: 3.325
Authors: Jacob A Clarke; Alyssa M Despotis; Ricardo J Ramirez; Jose P Zevallos; Angela L Mazul Journal: Cancer Epidemiol Biomarkers Prev Date: 2020-07-29 Impact factor: 4.090
Authors: Siddharth Sheth; Douglas R Farquhar; Nicholas R Lenze; Angela Mazul; Paul Brennan; Devasena Anantharaman; Behnoush Abedi-Ardekani; Jose P Zevallos; D Neil Hayes; F Olshan Journal: Am J Otolaryngol Date: 2020-10-22 Impact factor: 1.808