Arnaud Martel1,2, Aurélie Oberic3, Alexandre Moulin3, Leonidas Zografos3, Mehrad Hamedani3. 1. Jules'Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland. arnaudmartel@hotmail.fr. 2. Ophthalmology department, University Hospital of Nice, Nice, France. arnaudmartel@hotmail.fr. 3. Jules'Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland.
Abstract
PURPOSE: To report the clinical and histopathologic features of two cases of eyelids metastases from uveal melanoma diagnosed in a metachronous and synchronous fashion. METHODS: Monocentric retrospective case series of histopathologically proven eyelids metastases from uveal melanoma at our institution. RESULTS: Two patients were presented to our hospital for upper eyelids pigmented and firm lesions. Patient 1 had an history of left uveal melanoma treated conservatively with proton beam therapy 5 years earlier. Examination revealed bilateral upper eyelids lesions. Patient 2 had no malignancy history but was incidentally diagnosed with a cerebral nodule few months earlier. Examination revealed a right upper eyelid nodule and a previously unknown right uveal melanoma. Excisional biopsy was performed for both patients. Pathological assessment allowed the presence of melanoma cells. The lack of BAP1 nuclear expression on immunohistochemistry as well as the absence of cutaneous or mucosal melanoma were consistent with an uveal origin. Diffuse metastatic spread was noted for both patients. Systemic therapies were prescribed. Patient 1 died from metastatic spread (62 months and 4 months after uveal melanoma diagnosis and eyelids metastases removal, respectively) whereas patient 2 was still alive (14 months follow up). CONCLUSIONS: Eyelids metastases from uveal melanoma is an exceptional finding. Excisional biopsy and pathological assessment are of main importance to confirm the diagnosis and to identify genetic mutations for further targeted therapies. Currently, prognosis remains poor.
PURPOSE: To report the clinical and histopathologic features of two cases of eyelids metastases from uveal melanoma diagnosed in a metachronous and synchronous fashion. METHODS: Monocentric retrospective case series of histopathologically proven eyelids metastases from uveal melanoma at our institution. RESULTS: Two patients were presented to our hospital for upper eyelids pigmented and firm lesions. Patient 1 had an history of left uveal melanoma treated conservatively with proton beam therapy 5 years earlier. Examination revealed bilateral upper eyelids lesions. Patient 2 had no malignancy history but was incidentally diagnosed with a cerebral nodule few months earlier. Examination revealed a right upper eyelid nodule and a previously unknown right uveal melanoma. Excisional biopsy was performed for both patients. Pathological assessment allowed the presence of melanoma cells. The lack of BAP1 nuclear expression on immunohistochemistry as well as the absence of cutaneous or mucosal melanoma were consistent with an uveal origin. Diffuse metastatic spread was noted for both patients. Systemic therapies were prescribed. Patient 1 died from metastatic spread (62 months and 4 months after uveal melanoma diagnosis and eyelids metastases removal, respectively) whereas patient 2 was still alive (14 months follow up). CONCLUSIONS: Eyelids metastases from uveal melanoma is an exceptional finding. Excisional biopsy and pathological assessment are of main importance to confirm the diagnosis and to identify genetic mutations for further targeted therapies. Currently, prognosis remains poor.
Authors: Antonio Martorell-Calatayud; Celia Requena; José Luis Díaz-Recuero; Rosario Haro; José Luis Sarasa; Onofre Sanmartín; Rafael Botella-Estrada; Mar Burgués Calderón; Carlos Guillén Barona; Luis Requena Journal: Am J Dermatopathol Date: 2010-02 Impact factor: 1.533
Authors: A Y Bedikian; S S Legha; G Mavligit; C H Carrasco; S Khorana; C Plager; N Papadopoulos; R S Benjamin Journal: Cancer Date: 1995-11-01 Impact factor: 6.860