Literature DB >> 30560259

Selenols: a new class of carbonic anhydrase inhibitors.

Andrea Angeli1, Damiano Tanini, Alessio Nocentini, Antonella Capperucci, Marta Ferraroni, Paola Gratteri, Claudiu T Supuran.   

Abstract

Stable aryl selenols were obtained through a convenient procedure. Selenols represent a new chemotype acting as carbonic anhydrase inhibitors (CAIs), inhibiting four human isoforms, CAs I, II, VII and the tumor-associated CA IX. X-ray crystallographic, physical and computational studies provided insights into the binding mode of this conceptually new class of CAIs.

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Year:  2019        PMID： 30560259     DOI： 10.1039/c8cc08562e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

Review 1.  Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies.

Authors:  Mateusz Kciuk; Adrianna Gielecińska; Somdutt Mujwar; Mariusz Mojzych; Beata Marciniak; Rafał Drozda; Renata Kontek
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756

Review 2.  Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase.

Authors:  Alessio Nocentini; Andrea Angeli; Fabrizio Carta; Jean-Yves Winum; Raivis Zalubovskis; Simone Carradori; Clemente Capasso; William A Donald; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

3.  Selenocarbamates As a Prodrug-Based Approach to Carbonic Anhydrase Inhibition.

Authors:  Andrea Angeli; Marta Ferraroni; Antonella Capperucci; Damiano Tanini; Gabriele Costantino; Claudiu T Supuran
Journal:  ChemMedChem       Date:  2022-03-23       Impact factor: 3.540

4.  Evaluation of Thio- and Seleno-Acetamides Bearing Benzenesulfonamide as Inhibitor of Carbonic Anhydrases from Different Pathogenic Bacteria.

Authors:  Andrea Angeli; Mariana Pinteala; Stelian S Maier; Bogdan C Simionescu; Andrea Milaneschi; Ghulam Abbas; Sonia Del Prete; Clemente Capasso; Antonella Capperucci; Damiano Tanini; Fabrizio Carta; Claudiu T Supuran
Journal:  Int J Mol Sci       Date:  2020-01-17       Impact factor: 5.923

5.  Sulfonamide Inhibition Studies of an α-Carbonic Anhydrase from Schistosoma mansoni, a Platyhelminth Parasite Responsible for Schistosomiasis.

Authors:  Andrea Angeli; Mariana Pinteala; Stelian S Maier; Bogdan C Simionescu; Akram A Da'dara; Patrick J Skelly; Claudiu T Supuran
Journal:  Int J Mol Sci       Date:  2020-03-07       Impact factor: 5.923
  5 in total

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