M Elisabeth Koopman-Verhoeff1, Koen Bolhuis2, Charlotte A M Cecil3, Desana Kocevska4, James J Hudziak5, Manon H J Hillegers6, Viara R Mileva-Seitz7, Irwin K Reiss8, Liesbeth Duijts9, Frank Verhulst10, Maartje P C M Luijk11, Henning Tiemeier12. 1. Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre-Sophia Children's Hospital, Rotterdam, the Netherlands; The Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands. Electronic address: m.verhoeff@erasmusmc.nl. 2. Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre-Sophia Children's Hospital, Rotterdam, the Netherlands; The Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands. Electronic address: k.bolhuis@erasmusmc.nl. 3. Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre-Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Electronic address: c.cecil@erasmusmc.nl. 4. Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre-Sophia Children's Hospital, Rotterdam, the Netherlands; The Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, the Netherlands. Electronic address: d.kocevska@erasmusmc.nl. 5. Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre-Sophia Children's Hospital, Rotterdam, the Netherlands; Departments of Psychiatry, Medicine and Pediatrics, College of Medicine, University of Vermont, Burlington, VT, USA. Electronic address: james.hudziak@med.uvm.edu. 6. Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre-Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Psychiatry, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, the Netherlands. Electronic address: m.hillegers@erasmusmc.nl. 7. Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre-Sophia Children's Hospital, Rotterdam, the Netherlands. Electronic address: viara.mileva@gmail.com. 8. Department of Pediatrics, Erasmus University Medical Centre, Sophia Children's Hospital, Rotterdam, the Netherlands. Electronic address: i.reiss@erasmusmc.nl. 9. Department of Pediatrics, Erasmus University Medical Centre, Sophia Children's Hospital, Rotterdam, the Netherlands. Electronic address: l.duijts@erasmusmc.nl. 10. Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre-Sophia Children's Hospital, Rotterdam, the Netherlands; Child and Adolescent Mental Health Centre, Mental Health Services Capital Region, Research Unit, Copenhagen University Hospital, Copenhagen, Denmark. Electronic address: f.verhulst@erasmusmc.nl. 11. Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre-Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Psychology, Education & Child Studies, Erasmus University Rotterdam, Rotterdam, the Netherlands. Electronic address: luijk@essb.eur.nl. 12. Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre-Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Social and Behavioral Science, Harvard TH Chan School of Public Health, Boston, USA. Electronic address: tiemeier@hsph.harvard.edu.
Abstract
BACKGROUND: Psychotic experiences comprise auditory and visual perceptive phenomena, such as hearing or seeing things that are not there, in the absence of a psychotic disorder. Psychotic experiences commonly occur in the general pediatric population. Although the majority of psychotic experiences are transient, they are predictive of future psychotic and non-psychotic disorders. They have been associated with sleep problems, but studies with objective sleep measures are lacking. This study assessed whether psychotic experiences were associated with actigraphic sleep measures, symptoms of dyssomnia, nightmares, or other parasomnias. METHODS: This cross-sectional population-based study comprises 4149 children from the Generation R Study. At age 10 years, psychotic experiences including hallucinatory phenomena were assessed by self-report; dyssomnia and parasomnia symptoms were assessed by mother- and child-report. Additionally, at age 11 years, objective sleep parameters were measured using a tri-axial wrist accelerometer in N = 814 children, who wore the accelerometer for five consecutive school days. RESULTS: Psychotic experiences were not associated with objective sleep duration, sleep efficiency, arousal, or social jetlag. However, psychotic experiences were associated with self-reported dyssomnia (B = 2.45, 95%CI: 2.13-2.77, p < 0.001) and mother-reported parasomnia, specifically nightmares (ORadjusted = 3.59, 95%CI 2.66-4.83, p < 0.001). Similar results were found when analyses were restricted to hallucinatory phenomena. CONCLUSIONS: Childhood psychotic experiences were not associated with objective sleep measures. In contrast, psychotic experiences were associated with nightmares, which are a known risk indicator of psychopathology in pre-adolescence. More research is needed to shed light on the potential etiologic or diagnostic role of nightmares in the development of psychotic phenomena.
BACKGROUND:Psychotic experiences comprise auditory and visual perceptive phenomena, such as hearing or seeing things that are not there, in the absence of a psychotic disorder. Psychotic experiences commonly occur in the general pediatric population. Although the majority of psychotic experiences are transient, they are predictive of future psychotic and non-psychotic disorders. They have been associated with sleep problems, but studies with objective sleep measures are lacking. This study assessed whether psychotic experiences were associated with actigraphic sleep measures, symptoms of dyssomnia, nightmares, or other parasomnias. METHODS: This cross-sectional population-based study comprises 4149 children from the Generation R Study. At age 10 years, psychotic experiences including hallucinatory phenomena were assessed by self-report; dyssomnia and parasomnia symptoms were assessed by mother- and child-report. Additionally, at age 11 years, objective sleep parameters were measured using a tri-axial wrist accelerometer in N = 814 children, who wore the accelerometer for five consecutive school days. RESULTS:Psychotic experiences were not associated with objective sleep duration, sleep efficiency, arousal, or social jetlag. However, psychotic experiences were associated with self-reported dyssomnia (B = 2.45, 95%CI: 2.13-2.77, p < 0.001) and mother-reported parasomnia, specifically nightmares (ORadjusted = 3.59, 95%CI 2.66-4.83, p < 0.001). Similar results were found when analyses were restricted to hallucinatory phenomena. CONCLUSIONS: Childhood psychotic experiences were not associated with objective sleep measures. In contrast, psychotic experiences were associated with nightmares, which are a known risk indicator of psychopathology in pre-adolescence. More research is needed to shed light on the potential etiologic or diagnostic role of nightmares in the development of psychotic phenomena.
Authors: Maria Elisabeth Koopman-Verhoeff; Fadila Serdarevic; Desana Kocevska; F Fenne Bodrij; Viara R Mileva-Seitz; Irwin Reiss; Manon H J Hillegers; Henning Tiemeier; Charlotte A M Cecil; Frank C Verhulst; Maartje P C M Luijk Journal: J Child Psychol Psychiatry Date: 2019-04-03 Impact factor: 8.982
Authors: Maria Elisabeth Koopman-Verhoeff; Rosa H Mulder; Jared M Saletin; Irwin Reiss; Gijsbertus T J van der Horst; Janine F Felix; Mary A Carskadon; Henning Tiemeier; Charlotte A M Cecil Journal: J Child Psychol Psychiatry Date: 2020-05-03 Impact factor: 8.982
Authors: Elisabet Blok; M Elisabeth Koopman-Verhoeff; Daniel P Dickstein; Jared Saletin; Annemarie I Luik; Jolien Rijlaarsdam; Manon Hillegers; Desana Kocevska; Tonya White; Henning Tiemeier Journal: Child Adolesc Psychiatry Ment Health Date: 2022-02-17 Impact factor: 3.033
Authors: Lisa R Steenkamp; Henning Tiemeier; Laura M E Blanken; Manon H J Hillegers; Steven A Kushner; Koen Bolhuis Journal: Br J Psychiatry Date: 2021-12 Impact factor: 9.319