Adriane Mailhac1, José Labarere2, Florent Aptel1, Sylvie Berthemy3, Laurence Bouillet4, Christophe Chiquet5. 1. Grenoble Alpes University, Grenoble, France; Department of Ophthalmology, Grenoble Alpes University Hospital, Grenoble, France. 2. Grenoble Alpes University, Grenoble, France; Quality of Care Unit, CIC 1406 INSERM, University Hospital, Grenoble, France. 3. Grenoble Alpes University, Grenoble, France. 4. Grenoble Alpes University, Grenoble, France; Department of Internal Medicine, Grenoble Alpes University Hospital, Grenoble, France. 5. Grenoble Alpes University, Grenoble, France; Department of Ophthalmology, Grenoble Alpes University Hospital, Grenoble, France. Electronic address: christophe.chiquet@inserm.fr.
Abstract
PURPOSE: The aim of this study is to investigate temporal trends in multifocal ERG (mfERG) parameters and analyze their relationships with anatomic and functional markers in patients with birdshot chorioretinopathy (BSCR). DESIGN: Prospective observational case series. METHODS: Sixteen BSCR patients were include and underwent 2 standardized follow-up (FU) visits within 5 years following a baseline examination, including mfERG, visual acuity (VA), visual field (VF), Lanthony desaturated panel D-15 test for color vision, quality of life (QoL), fluorescein and indocyanine green angiography, and optical coherence tomography (OCT). RESULTS: A significant trend toward a decrease in absolute N1 amplitude values was observed over the follow-up period (P < .001) while N1 implicit time remained unchanged. In contrast, P1 amplitude decreased (P < .001) and P1 implicit time increased (P < .001) over the same period. No significant temporal change was found for VA, color vision score, foveal threshold, mean deviation of VF, and QoL. After adjusting for time to FU, increasing N1 and P1 IT were both associated with decreasing values of logMAR, foveal threshold, and QoL and with increasing color vision score and mean deviation of VF. A significant relationship was observed between decreasing P1 amplitude values and increasing mean deviation of VF. Lower absolute values of N1 amplitude were associated with venous vasculitis, whereas lower P1 amplitude values correlated with alteration of the outer retina in OCT. CONCLUSIONS: Progressive deterioration in mfERG during a 5-year period is detected in BSCR, whereas classical functional test results were unchanged. This study suggests a better sensitivity of mfERG in monitoring the retinal function of BSCR patients.
PURPOSE: The aim of this study is to investigate temporal trends in multifocal ERG (mfERG) parameters and analyze their relationships with anatomic and functional markers in patients with birdshot chorioretinopathy (BSCR). DESIGN: Prospective observational case series. METHODS: Sixteen BSCR patients were include and underwent 2 standardized follow-up (FU) visits within 5 years following a baseline examination, including mfERG, visual acuity (VA), visual field (VF), Lanthony desaturated panel D-15 test for color vision, quality of life (QoL), fluorescein and indocyanine green angiography, and optical coherence tomography (OCT). RESULTS: A significant trend toward a decrease in absolute N1 amplitude values was observed over the follow-up period (P < .001) while N1 implicit time remained unchanged. In contrast, P1 amplitude decreased (P < .001) and P1 implicit time increased (P < .001) over the same period. No significant temporal change was found for VA, color vision score, foveal threshold, mean deviation of VF, and QoL. After adjusting for time to FU, increasing N1 and P1 IT were both associated with decreasing values of logMAR, foveal threshold, and QoL and with increasing color vision score and mean deviation of VF. A significant relationship was observed between decreasing P1 amplitude values and increasing mean deviation of VF. Lower absolute values of N1 amplitude were associated with venous vasculitis, whereas lower P1 amplitude values correlated with alteration of the outer retina in OCT. CONCLUSIONS: Progressive deterioration in mfERG during a 5-year period is detected in BSCR, whereas classical functional test results were unchanged. This study suggests a better sensitivity of mfERG in monitoring the retinal function of BSCR patients.
Authors: Anna M Waldie; Angharad E Hobby; Isabelle Chow; Elisa E Cornish; Mathura Indusegaran; Aleksandra Pekacka; Phuc Nguyen; Clare Fraser; Alison M Binns; Miles R Stanford; Christopher J Hammond; Peter J McCluskey; John R Grigg; Omar A Mahroo Journal: Transl Vis Sci Technol Date: 2022-05-02 Impact factor: 3.048
Authors: Elodie Bousquet; Pierre Duraffour; Louis Debillon; Swathi Somisetty; Dominique Monnet; Antoine P Brézin Journal: J Clin Med Date: 2022-08-16 Impact factor: 4.964