Elena Martínez1, Nancy Portillo2, Eneritz Lizarralde3, Gema Grau4, Amaia Vela5, Amaia Rodríguez4, Itxaso Rica6.
Abstract
Although the treatment of pediatric patients with T1DM has improved ketoacidosis (DKA) remains a frequent problem.
OBJECTIVE: To estimate temporal changes in the prevalence of DKA at diagnosis of T1DM and to explore the factors associated with its occurrence.
METHODS: Paediatric patients diagnosed at Cruces University Hospital (Spain) since 1997 were included. Clinical/analytical variables at diabetes onset, Hemoglobin A1c level during the first 2 years of evolution and the presence of the honeymoon phase were studied.
RESULTS: In 209 patients the prevalence of DKA was stable over time and high (35.4%) especially in the youngest. 8.5% of patients had a severe DKA with a higher risk in older than 10. Partial remission occurred in 26% patients, less frequent in the youngest and in the subgroup with DKA at diagnosis.
CONCLUSION: The frequency of DKA although stable, remains high and is associated with a worse evolution of the disease. Copyright© of YS Medical Media ltd.
Although the treatment of pediatric patients with T1DM has improved ketoacidosis (DKA) remains a frequent problem.
OBJECTIVE: To estimate temporal changes in the prevalence of DKA at diagnosis of T1DM and to explore the factors associated with its occurrence.
METHODS: Paediatric patients diagnosed at Cruces University Hospital (Spain) since 1997 were included. Clinical/analytical variables at diabetes onset, Hemoglobin A1c level during the first 2 years of evolution and the presence of the honeymoon phase were studied.
RESULTS: In 209 patients the prevalence of DKA was stable over time and high (35.4%) especially in the youngest. 8.5% of patients had a severe DKA with a higher risk in older than 10. Partial remission occurred in 26% patients, less frequent in the youngest and in the subgroup with DKA at diagnosis.
CONCLUSION: The frequency of DKA although stable, remains high and is associated with a worse evolution of the disease. Copyright© of YS Medical Media ltd.
Entities:
Keywords:
Childhood; Diabetic Ketoacidosis; Honeymoon phase; Type 1 Diabetes mellitus
Mesh：
Substances：
Year: 2018
PMID： 30556656 DOI： 10.17458/per.vol16.2018.mpr.fd.t1dmdka
Source DB: PubMed Journal: Pediatr Endocrinol Rev ISSN： 1565-4753