Francesco Giovacchini1, Caterina Bensi2, Stefano Belli2, Maria Elena Laurenti3, Martina Mandarano3, Daniele Paradiso4, Michele Giansanti3, Antonio Tullio1,2,3,4,5. 1. Maxillo-Facial Surgery Unit, S. Maria della Misericordia Hospital, Piazza Menghini 1, San Sisto, Perugia, Italy. 2. Department of Surgical and Biomedical Sciences, University of Perugia, Piazza Gambuli 1, San Sisto, Perugia, Italy. 3. Department of Experimental Medicine, Section of Anatomic Pathology and Histology, University of Perugia, Piazza Menghini 1, San Sisto, Perugia, Italy. 4. S.S.D. of Oral Surgery and Ambulatory, S. Maria della Misericordia Hospital, Piazza Menghini 1, San Sisto, Perugia, Italy. 5. Maxillo-Facial Surgery, University of Perugia, Piazza Gambuli 1, San Sisto, Perugia, Italy.
Abstract
BACKGROUND: Low-grade intraductal carcinomas are rare, malign tumors of salivary glands most commonly affecting parotid gland. It is a slow-growing tumor considered with a favourable prognosis after surgical excision. METHODS: To define the characteristics and management of low-grade intraductal carcinoma a systematic review was performed using the electronic databases Pubmed, Cochrane and Scopus. A new case report was also described. RESULTS: Including this case the review of literature identified only 54 cases reported thus far. Demographics, clinical presentation, diagnostic tools, treatment, follow-up and recurrence rate, histological and immunohistochemical patterns of this kind of tumor were summarized. CONCLUSION: Low-grade intraductal carcinoma has already been well defined but is important to focus on the fact that in few cases component of high-grade infiltrations have been reported: this may modify surgical approach because a simple tumorectomy may not be enough.
BACKGROUND: Low-grade intraductal carcinomas are rare, malign tumors of salivary glands most commonly affecting parotid gland. It is a slow-growing tumor considered with a favourable prognosis after surgical excision. METHODS: To define the characteristics and management of low-grade intraductal carcinoma a systematic review was performed using the electronic databases Pubmed, Cochrane and Scopus. A new case report was also described. RESULTS: Including this case the review of literature identified only 54 cases reported thus far. Demographics, clinical presentation, diagnostic tools, treatment, follow-up and recurrence rate, histological and immunohistochemical patterns of this kind of tumor were summarized. CONCLUSION: Low-grade intraductal carcinoma has already been well defined but is important to focus on the fact that in few cases component of high-grade infiltrations have been reported: this may modify surgical approach because a simple tumorectomy may not be enough.
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