Amy W Amara1, Lana Chahine2, Nicholas Seedorff3, Chelsea J Caspell-Garcia3, Christopher Coffey3, Tanya Simuni4. 1. Department of Neurology, The University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: amyamara@uab.edu. 2. Department of Neurology, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA. 3. Department of Biostatistics, The University of Iowa, Iowa City, IA, USA. 4. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Abstract
INTRODUCTION: This study investigates longitudinal changes in self-reported physical activity, measured by Physical Activity Scale of the Elderly (PASE), in early Parkinson's disease (PD) and matched healthy control (HC) participants in the Parkinson's Progression Marker Initiative (PPMI) and evaluates associations between physical activity and PD progression. METHODS: PPMI is a prospective, longitudinal study evaluating markers of progression in PD participants who are unmedicated at enrollment. PASE, a self-reported measure of physical activity, was administered to early PD (N = 380) and HC (N = 174). PASE was introduced after study launch and therefore administered at years 2, 3, and 4. PASE scores for PD and HC were compared with t-tests and changes over time were evaluated with generalized estimating equations. RESULTS: There were no differences in activity levels between PD and HC at any time point. However, PD participants had a longitudinal decrease in PASE from years two to four (p = 0.034), while HC did not (p = 0.89). In exploratory analyses controlling for age, sex, and disease duration, higher self-reported activity at year 2 were associated with slower progression of motor symptoms (p = 0.018), ADL performance (p < 0.0001), depression (p = 0.001), anxiety (p = 0.002), and cognitive decline (p = 0.016) over two years. These findings remained significant after adjusting for disease severity. CONCLUSION: There are no differences in self-reported physical activity between HC and early PD, but activity levels decline longitudinally in PD. Exploratory analyses show that higher self-reported physical activity is associated with less disease progression. Therefore, interventions to increase physical activity in early PD could potentially modify the disease course.
INTRODUCTION: This study investigates longitudinal changes in self-reported physical activity, measured by Physical Activity Scale of the Elderly (PASE), in early Parkinson's disease (PD) and matched healthy control (HC) participants in the Parkinson's Progression Marker Initiative (PPMI) and evaluates associations between physical activity and PD progression. METHODS: PPMI is a prospective, longitudinal study evaluating markers of progression in PDparticipants who are unmedicated at enrollment. PASE, a self-reported measure of physical activity, was administered to early PD (N = 380) and HC (N = 174). PASE was introduced after study launch and therefore administered at years 2, 3, and 4. PASE scores for PD and HC were compared with t-tests and changes over time were evaluated with generalized estimating equations. RESULTS: There were no differences in activity levels between PD and HC at any time point. However, PDparticipants had a longitudinal decrease in PASE from years two to four (p = 0.034), while HC did not (p = 0.89). In exploratory analyses controlling for age, sex, and disease duration, higher self-reported activity at year 2 were associated with slower progression of motor symptoms (p = 0.018), ADL performance (p < 0.0001), depression (p = 0.001), anxiety (p = 0.002), and cognitive decline (p = 0.016) over two years. These findings remained significant after adjusting for disease severity. CONCLUSION: There are no differences in self-reported physical activity between HC and early PD, but activity levels decline longitudinally in PD. Exploratory analyses show that higher self-reported physical activity is associated with less disease progression. Therefore, interventions to increase physical activity in early PD could potentially modify the disease course.
Authors: Philipp Zimmer; Martina E Schmidt; Mirja Tamara Prentzell; Bianca Berdel; Joachim Wiskemann; Karl Heinz Kellner; Jürgen Debus; Cornelia Ulrich; Christiane A Opitz; Karen Steindorf Journal: Front Oncol Date: 2019-09-25 Impact factor: 6.244
Authors: Joomee Song; Jinyoung Youn; Young Eun Huh; Jun Kyu Mun; Jong Hyeon Ahn; Dongyeong Lee; Woo Young Shin; Jin Whan Cho Journal: Front Neurol Date: 2021-11-30 Impact factor: 4.003
Authors: Silvia Del Din; Brook Galna; Sue Lord; Alice Nieuwboer; Esther M J Bekkers; Elisa Pelosin; Laura Avanzino; Bastiaan R Bloem; Marcel G M Olde Rikkert; Freek Nieuwhof; Andrea Cereatti; Ugo Della Croce; Anat Mirelman; Jeffrey M Hausdorff; Lynn Rochester Journal: J Gerontol A Biol Sci Med Sci Date: 2020-05-22 Impact factor: 6.053