Literature DB >> 30554913

From Discovery to Bedside: Targeting the Ubiquitin System.

Ingrid E Wertz1, Xiaojing Wang2.   

Abstract

The ubiquitin/proteasome system is a primary conduit for selective intracellular protein degradation. Since its discovery over 30 years ago, this highly regulated system continues to be an active research area for drug discovery that is exemplified by several approved drugs. Here we review compounds in preclinical testing, clinical trials, and approved drugs, with the aim of highlighting innovative discoveries and breakthrough therapies that target the ubiquitin system.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Keywords:  DUB; E3; degradation; deubiquitinase; proteasome; ubiquitin; ubiquitin ligase

Mesh：

Substances：

Year:  2018        PMID： 30554913     DOI： 10.1016/j.chembiol.2018.10.022

Source DB:  PubMed          Journal:  Cell Chem Biol        ISSN： 2451-9448            Impact factor:   8.116


  37 in total

Review 1.  Protein-protein interaction modulators: advances, successes and remaining challenges.

Authors:  Lloyd Mabonga; Abidemi Paul Kappo
Journal:  Biophys Rev       Date:  2019-07-12

Review 2.  Modulating protein-protein interaction networks in protein homeostasis.

Authors:  Mengqi Zhong; Gregory M Lee; Eline Sijbesma; Christian Ottmann; Michelle R Arkin
Journal:  Curr Opin Chem Biol       Date:  2019-03-23       Impact factor: 8.822

Review 3.  SAGA-Dependent Histone H2Bub1 Deubiquitination Is Essential for Cellular Ubiquitin Balance during Embryonic Development.

Authors:  Farrah El-Saafin; Didier Devys; Steven A Johnsen; Stéphane D Vincent; László Tora
Journal:  Int J Mol Sci       Date:  2022-07-05       Impact factor: 6.208

Review 4.  Minor structural changes, major functional impacts: posttranslational modifications and drug targets.

Authors:  Hyo Jung Kim
Journal:  Arch Pharm Res       Date:  2022-10-17       Impact factor: 6.010

5.  A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2.

Authors:  Kenta Kamikubo; Hisakazu Kato; Hidetaka Kioka; Satoru Yamazaki; Osamu Tsukamoto; Yuya Nishida; Yoshihiro Asano; Hiromi Imamura; Hiroyuki Kawahara; Yasunori Shintani; Seiji Takashima
Journal:  J Biol Chem       Date:  2019-08-01       Impact factor: 5.157

6.  The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis.

Authors:  Xingyun Wang; Shilin Xia; Hongchang Li; Xiang Wang; Chaonan Li; Yulin Chao; Lingqiang Zhang; Chuanchun Han
Journal:  Cell Death Differ       Date:  2019-11-20       Impact factor: 15.828

Review 7.  Decoding the messaging of the ubiquitin system using chemical and protein probes.

Authors:  Lukas T Henneberg; Brenda A Schulman
Journal:  Cell Chem Biol       Date:  2021-04-07       Impact factor: 8.116

8.  TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4.

Authors:  Qian Ou; Jia-Qi Fang; Zhe-Sheng Zhang; Zhe Chi; Jie Fang; Di-Yan Xu; Kai-Zhong Lu; Meng-Qing Qian; Da-Yong Zhang; Jun-Ping Guo; Wei Gao; Na-Ru Zhang; Jian-Ping Pan
Journal:  Nat Commun       Date:  2021-06-09       Impact factor: 14.919

9.  Activation of E6AP/UBE3A-Mediated Protein Ubiquitination and Degradation Pathways by a Cyclic γ-AA Peptide.

Authors:  Bo Huang; Li Zhou; Ruochuan Liu; Lei Wang; Songyi Xue; Yan Shi; Geon Ho Jeong; In Ho Jeong; Sihao Li; Jun Yin; Jianfeng Cai
Journal:  J Med Chem       Date:  2022-01-19       Impact factor: 7.446

Review 10.  Regulation of Deubiquitinating Enzymes by Post-Translational Modifications.

Authors:  Tanuza Das; Sang Chul Shin; Eun Joo Song; Eunice EunKyeong Kim
Journal:  Int J Mol Sci       Date:  2020-06-04       Impact factor: 5.923
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