Rachele De Giuseppe1, Valeria Calcaterra2,3, Ginevra Biino4, Matteo Manuelli1, Noelia Rodriguez Mier1,5, Melissa Mantelli6, Maria De Filippo7,8, Gianguido Cossellu9, Hellas Cena1,10. 1. Dietetics and Clinical Nutrition Laboratory, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy. 2. Department of Maternal and Children's Health, Pediatric Endocrinology Unit, Fondazione IRCCS Policlinico S. Matteo, P.le Golgi n.2, 27100, Pavia, Italy. v.calcaterra@smatteo.pv.it. 3. Department of Internal Medicine, University of Pavia, Pavia, Italy. v.calcaterra@smatteo.pv.it. 4. Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy. 5. KU Leuven, Leuven, Belgium. 6. Immunology and Transplantation Laboratory/Cell Factory/Pediatric Hematology/Oncology Department, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy. 7. Department of Maternal and Children's Health, Pediatric Endocrinology Unit, Fondazione IRCCS Policlinico S. Matteo, P.le Golgi n.2, 27100, Pavia, Italy. 8. Department of Internal Medicine, University of Pavia, Pavia, Italy. 9. Department of Biomedical, Surgical and Dental Sciences, University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milano, Italy. 10. Clinical Nutrition and Dietetics Service, Unit of Internal Medicine and Endocrinology, ICS Maugeri IRCCS, University of Pavia, Pavia, Italy.
Abstract
PURPOSE: Oxidized LDL cholesterol (oxLDL) has been considered as a sensor of oxidative stress (OS) in childhood obesity. We integrated and related our oxLDL existing results previously assessed in overweight/obese children to lifestyle variables to investigate OS-related lifestyle variables. METHODS: 178 Caucasian children/adolescents have been evaluated and according to BMI percentiles have been classified as normal weight (BMI < 75th); overweight (BMI 75-97th) and obese (BMI > 97th). Serum oxLDL levels have been measured. The dietary habits and physical activity have been also assessed. RESULTS: No differences between normal weight and overweight/obese children were detected according to the total score of dietary habits section. Normal weight subjects reported a higher total physical activity score (p = 0.001) compared to overweight/ obese children. No correlation between oxLDL and total dietary habits and physical activity scores was noted. Increased oxLDL in subjects drinking < 1 L/day of water (p = 0.022) and in daily consumers of chocolate drinks at breakfast (p = 0.029) was observed, while a decreased oxLDL was reported in subjects consuming a breakfast based mainly on fruits (p = 0.004). Moreover, "high-fat diet" and "always eating a dessert at the end of the meal" were correlated with increased oxLDL with a trend towards significance. As regards physical activity, no correlations were observed. CONCLUSIONS: Diet and physical activity may not have an immediate impact on OS response in children with or without obesity. Unhealthy lifestyle, including increased fat, simple sugar intake, poor water intake, emerged as external exposome predictors of OS, that may be monitored to improve health status. LEVEL OF EVIDENCE: Level III, case-control analytic studies.
PURPOSE: Oxidized LDL cholesterol (oxLDL) has been considered as a sensor of oxidative stress (OS) in childhood obesity. We integrated and related our oxLDL existing results previously assessed in overweight/obesechildren to lifestyle variables to investigate OS-related lifestyle variables. METHODS: 178 Caucasian children/adolescents have been evaluated and according to BMI percentiles have been classified as normal weight (BMI < 75th); overweight (BMI 75-97th) and obese (BMI > 97th). Serum oxLDL levels have been measured. The dietary habits and physical activity have been also assessed. RESULTS: No differences between normal weight and overweight/obesechildren were detected according to the total score of dietary habits section. Normal weight subjects reported a higher total physical activity score (p = 0.001) compared to overweight/ obesechildren. No correlation between oxLDL and total dietary habits and physical activity scores was noted. Increased oxLDL in subjects drinking < 1 L/day of water (p = 0.022) and in daily consumers of chocolate drinks at breakfast (p = 0.029) was observed, while a decreased oxLDL was reported in subjects consuming a breakfast based mainly on fruits (p = 0.004). Moreover, "high-fat diet" and "always eating a dessert at the end of the meal" were correlated with increased oxLDL with a trend towards significance. As regards physical activity, no correlations were observed. CONCLUSIONS: Diet and physical activity may not have an immediate impact on OS response in children with or without obesity. Unhealthy lifestyle, including increased fat, simple sugar intake, poor water intake, emerged as external exposome predictors of OS, that may be monitored to improve health status. LEVEL OF EVIDENCE: Level III, case-control analytic studies.
Authors: Erica M Holt; Lyn M Steffen; Antoinette Moran; Samar Basu; Julia Steinberger; Julie A Ross; Ching-Ping Hong; Alan R Sinaiko Journal: J Am Diet Assoc Date: 2009-03
Authors: Alfonso M Lechuga-Sancho; David Gallego-Andujar; Pablo Ruiz-Ocaña; Francisco M Visiedo; Ana Saez-Benito; Mónica Schwarz; Carmen Segundo; Rosa M Mateos Journal: PLoS One Date: 2018-01-25 Impact factor: 3.240