Braxton D Mitchell1, Gurmannat Kalra2, Kathleen A Ryan2, Man Zhang2, Carole Sztalryd2, Nanette I Steinle2, Simeon I Taylor2, Soren Snitker2, Joshua P Lewis2, Michael Miller3, Alan R Shuldiner2, Huichun Xu2. 1. Program in Personalized and Genomic Medicine, and Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA. Electronic address: bmitchel@som.umaryland.edu. 2. Program in Personalized and Genomic Medicine, and Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD. 3. Division of Cardiovascular Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Abstract
BACKGROUND: Postprandial lipemia (PPL), defined as a prolonged or elevated rise in triglycerides that accompanies fat feeding, is a significant risk factor for coronary heart disease and associated comorbidities. The impact of PPL on coronary heart disease risk is underscored by the preponderance of each day spent in the postprandial state. OBJECTIVE: In this study, we evaluated cross-sectionally the association between usual (ie, noninterventional) physical activity and the 6-hour triglyceride response to a standardized high-fat meal. METHODS: The high-fat meal intervention was carried out in 671 apparently healthy individuals as part of the Heredity and Phenotype Intervention Heart Study. Triglyceride levels were measured in the fasting state and during 6 hours after administration of a standardized fat challenge. We defined PPL response as the triglyceride area under the fat load curve (AUC) and measured physical activity using accelerometers that were worn continuously over a 7-day period. RESULTS: Physical activity levels decreased with increasing age and were higher in men than women (both P < .001). The triglyceride AUC increased with increasing age in both men and women (both P < .001) and was also higher in men than in women (age-adjusted P = 9.2 × 10-12). Higher physical activity levels were associated with a lower triglyceride AUC (P = .003), adjusting for age, sex, body mass index, and fasting low-density lipoprotein. CONCLUSION: These results suggest that the protective benefits of physical activity on cardiovascular health may operate, at least in part, through reduction of the PPL triglyceride response.
BACKGROUND: Postprandial lipemia (PPL), defined as a prolonged or elevated rise in triglycerides that accompanies fat feeding, is a significant risk factor for coronary heart disease and associated comorbidities. The impact of PPL on coronary heart disease risk is underscored by the preponderance of each day spent in the postprandial state. OBJECTIVE: In this study, we evaluated cross-sectionally the association between usual (ie, noninterventional) physical activity and the 6-hour triglyceride response to a standardized high-fat meal. METHODS: The high-fat meal intervention was carried out in 671 apparently healthy individuals as part of the Heredity and Phenotype Intervention Heart Study. Triglyceride levels were measured in the fasting state and during 6 hours after administration of a standardized fat challenge. We defined PPL response as the triglyceride area under the fat load curve (AUC) and measured physical activity using accelerometers that were worn continuously over a 7-day period. RESULTS: Physical activity levels decreased with increasing age and were higher in men than women (both P < .001). The triglyceride AUC increased with increasing age in both men and women (both P < .001) and was also higher in men than in women (age-adjusted P = 9.2 × 10-12). Higher physical activity levels were associated with a lower triglyceride AUC (P = .003), adjusting for age, sex, body mass index, and fasting low-density lipoprotein. CONCLUSION: These results suggest that the protective benefits of physical activity on cardiovascular health may operate, at least in part, through reduction of the PPLtriglyceride response.
Authors: Braxton D Mitchell; Patrick F McArdle; Haiqing Shen; Evadnie Rampersaud; Toni I Pollin; Lawrence F Bielak; Cashell Jaquish; Julie A Douglas; Marie-Hélène Roy-Gagnon; Paul Sack; Rosalie Naglieri; Scott Hines; Richard B Horenstein; Yen-Pei C Chang; Wendy Post; Kathleen A Ryan; Nga Hong Brereton; Ruth E Pakyz; John Sorkin; Coleen M Damcott; Jeffrey R O'Connell; Charles Mangano; Mary Corretti; Robert Vogel; William Herzog; Matthew R Weir; Patricia A Peyser; Alan R Shuldiner Journal: Am Heart J Date: 2008-03-05 Impact factor: 4.749
Authors: P H Groot; W A van Stiphout; X H Krauss; H Jansen; A van Tol; E van Ramshorst; S Chin-On; A Hofman; S R Cresswell; L Havekes Journal: Arterioscler Thromb Date: 1991 May-Jun
Authors: Dale W Esliger; Mark S Tremblay; Jennifer L Copeland; Joel D Barnes; Gertrude E Huntington; David R Bassett Journal: Med Sci Sports Exerc Date: 2010-02 Impact factor: 5.411
Authors: Lawrence F Bielak; Panfong Yu; Kathleen A Ryan; John A Rumberger; Patrick F Sheedy; Stephen T Turner; Wendy Post; Alan R Shuldiner; Braxton D Mitchell; Patricia A Peyser Journal: Atherosclerosis Date: 2007-03-26 Impact factor: 5.162
Authors: Evadnie Rampersaud; Braxton D Mitchell; Toni I Pollin; Mao Fu; Haiqing Shen; Jeffery R O'Connell; Julie L Ducharme; Scott Hines; Paul Sack; Rosalie Naglieri; Alan R Shuldiner; Soren Snitker Journal: Arch Intern Med Date: 2008-09-08
Authors: Colby S Teeman; Stephanie P Kurti; Brooke J Cull; Sam R Emerson; Mark D Haub; Sara K Rosenkranz Journal: Nutr Metab (Lond) Date: 2016-11-16 Impact factor: 4.169
Authors: Kristen G Hairston; Julie L Ducharme; Margarita S Treuth; Wen-Chi Hsueh; Ania M Jastreboff; Kathy A Ryan; Xiaolian Shi; Braxton D Mitchell; Alan R Shuldiner; Soren Snitker Journal: Diabetes Care Date: 2012-10-23 Impact factor: 19.112
Authors: Mohammad Farris Iman Leong Bin Abdullah; Kok Leng Tan; Salbiah Mohd Isa; Nur Sabrina Yusoff; Nelson Jeng Yeou Chear; Darshan Singh Journal: PLoS One Date: 2020-06-11 Impact factor: 3.240
Authors: Shisi He; Kathleen A Ryan; Elizabeth A Streeten; Patrick F McArdle; Melanie Daue; Donna Trubiano; Yvonne Rohrer; Patrick Donnelly; Maryann Drolet; Sylvia Newcomer; Susan Shaub; Nancy Weitzel; Alan R Shuldiner; Toni I Pollin; Braxton D Mitchell Journal: BMJ Open Diabetes Res Care Date: 2020-08