| Literature DB >> 30552917 |
Jodi L Karnell1, Sadiye Amcaoglu Rieder2, Rachel Ettinger3, Roland Kolbeck4.
Abstract
CD40 is a TNF receptor superfamily member expressed on both immune and non-immune cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L, predominantly expressed on activated CD4+ T cells, play a critical role in promoting germinal center formation and the production of class-switched antibodies. Non-hematopoietic cells expressing CD40 can also engage CD40L and trigger a pro-inflammatory response. This article will highlight what is known about the biology of the CD40-CD40L axis in humans and describe the potential contribution of CD40 signaling on both hematopoietic and non-hematopoietic cells to autoimmune disease pathogenesis. Additionally, novel therapeutic approaches to target this pathway, currently being evaluated in clinical trials, are discussed.Entities:
Keywords: Autoimmunity; CD40-CD40L pathway; Cell-mediated immunity; Germinal center; Humoral immunity; Novel therapeutics
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Year: 2018 PMID： 30552917 DOI： 10.1016/j.addr.2018.12.005
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470