Yuan-Chin Amy Lee1, Shuang Li1, Yuji Chen1, Qian Li2, Chien-Jen Chen3,4, Wan-Lun Hsu3, Pei-Jen Lou5, Cairong Zhu6, Jian Pan7, Hongbing Shen8, Hongxia Ma8, Lin Cai9, Baochang He9, Yu Wang10,11, Xiaoyan Zhou11,12, Qinghai Ji10,11, Baosen Zhou13, Wei Wu13, Jie Ma14, Paolo Boffetta15, Zuo-Feng Zhang16, Min Dai17, Mia Hashibe1. 1. Division of Public Health, Department of Family and Preventive Medicine, and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah. 2. Departments of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York. 3. Genomics Research Center, Academia Sinica, Taipei, Taiwan. 4. Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan. 5. Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan. 6. Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, Sichuan, China. 7. Department of Oral Surgery, West China Hospital of Stomatology, Sichuan University, Sichuan, China. 8. Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China. 9. Department of Epidemiology and Biostatistics, School of Public Health, Fujian Medical University, Fujian, China. 10. Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. 11. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. 12. Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China. 13. Department of Epidemiology, School of Public Health, China Medical University, Liaoning, China. 14. Department of Head & Neck Oncology, Henan Cancer Hospital, Henan, China. 15. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, New York. 16. Department of Epidemiology, and Center for Environmental Genomics, Fielding School of Public Health, University of California, Los Angeles, California. 17. National Office of Cancer Prevention and Control Cancer Institute and Hospital, and Chinese Academy of Medical Sciences, Beijing, China.
Abstract
BACKGROUND: The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer risk in East Asia. METHODS: A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. The odds ratio (OR) and 95% confidence interval (CI) were estimated using logistic regression. RESULTS: Head and neck cancer risks were elevated for tobacco (OR = 1.58), betel quid (OR = 8.23), and alcohol (OR = 2.29). The total attributable risk of tobacco and/or alcohol was 47.2%. Tobacco/alcohol appeared to account for a small proportion of head and neck cancer among women (attributable risk of 2.2%). Betel quid chewing alone accounted for 28.7% of head and neck cancer. CONCLUSIONS: Betel quid chewing is the strongest risk factor for oral cavity cancer in this Chinese population. Alcohol may play a larger role for head and neck cancer in this population than in European or U.S.
BACKGROUND: The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer risk in East Asia. METHODS: A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. The odds ratio (OR) and 95% confidence interval (CI) were estimated using logistic regression. RESULTS:Head and neck cancer risks were elevated for tobacco (OR = 1.58), betel quid (OR = 8.23), and alcohol (OR = 2.29). The total attributable risk of tobacco and/or alcohol was 47.2%. Tobacco/alcohol appeared to account for a small proportion of head and neck cancer among women (attributable risk of 2.2%). Betel quid chewing alone accounted for 28.7% of head and neck cancer. CONCLUSIONS: Betel quid chewing is the strongest risk factor for oral cavity cancer in this Chinese population. Alcohol may play a larger role for head and neck cancer in this population than in European or U.S.
Authors: Chun-Pin Chang; Bhola Siwakoti; Amir Sapkota; Dej K Gautam; Yuan-Chin Amy Lee; Marcus Monroe; Mia Hashibe Journal: Int J Cancer Date: 2019-12-27 Impact factor: 7.396