Lena M Thorn1,2, Sara Shams3, Daniel Gordin1,2,4, Ron Liebkind5, Carol Forsblom1,2, Paula Summanen1,2,6, Stefanie Hägg-Holmberg1,2, Turgut Tatlisumak5,7,8, Oili Salonen9, Jukka Putaala5, Juha Martola3,9, Per-Henrik Groop. 1. Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland. 2. Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland. 3. Department of Radiology, Karolinska University Hospital, and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden. 4. Joslin Diabetes Center, Harvard Medical School, Boston, MA. 5. Department of Neurology, Helsinki University Hospital, Helsinki, Finland. 6. Department of Ophthalmology, Helsinki University Hospital, Helsinki, Finland. 7. Department of Clinical Neuroscience/Neurology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. 8. Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden. 9. Department of Radiology, Helsinki University Hospital, Helsinki, Finland.
Abstract
OBJECTIVE: To assess the prevalence of cerebral small-vessel disease (SVD) in subjects with type 1 diabetes compared with healthy control subjects and to characterize the diabetes-related factors associated with SVD. RESEARCH DESIGN AND METHODS: This substudy was cross-sectional in design and included 191 participants with type 1 diabetes and median age 40.0 years (interquartile range 33.0-45.1) and 30 healthy age- and sex-matched control subjects. All participants underwent clinical investigation and brain MRIs, assessed for cerebral SVD. RESULTS: Cerebral SVD was more common in participants with type 1 diabetes than in healthy control subjects: any marker 35% vs. 10% (P = 0.005), cerebral microbleeds (CMBs) 24% vs. 3.3% (P = 0.008), white matter hyperintensities 17% vs. 6.7% (P = 0.182), and lacunes 2.1% vs. 0% (P = 1.000). Presence of CMBs was independently associated with systolic blood pressure (odds ratio 1.03 [95% CI 1.00-1.05], P = 0.035). CONCLUSIONS: Cerebral SVD, CMBs in particular, is more common in young people with type 1 diabetes compared with healthy control subjects.
OBJECTIVE: To assess the prevalence of cerebral small-vessel disease (SVD) in subjects with type 1 diabetes compared with healthy control subjects and to characterize the diabetes-related factors associated with SVD. RESEARCH DESIGN AND METHODS: This substudy was cross-sectional in design and included 191 participants with type 1 diabetes and median age 40.0 years (interquartile range 33.0-45.1) and 30 healthy age- and sex-matched control subjects. All participants underwent clinical investigation and brain MRIs, assessed for cerebral SVD. RESULTS:Cerebral SVD was more common in participants with type 1 diabetes than in healthy control subjects: any marker 35% vs. 10% (P = 0.005), cerebral microbleeds (CMBs) 24% vs. 3.3% (P = 0.008), white matter hyperintensities 17% vs. 6.7% (P = 0.182), and lacunes 2.1% vs. 0% (P = 1.000). Presence of CMBs was independently associated with systolic blood pressure (odds ratio 1.03 [95% CI 1.00-1.05], P = 0.035). CONCLUSIONS:Cerebral SVD, CMBs in particular, is more common in young people with type 1 diabetes compared with healthy control subjects.
Authors: Alan M Jacobson; Barbara H Braffett; Guray Erus; Christopher M Ryan; Geert J Biessels; José A Luchsinger; Ionut Bebu; Rose A Gubitosi-Klug; Lisa Desiderio; Gayle M Lorenzi; Victoria R Trapani; John M Lachin; R Nick Bryan; Mohamad Habes; Ilya M Nasrallah Journal: Diabetes Care Date: 2022-08-01 Impact factor: 17.152
Authors: Jussi Inkeri; Anniina Tynjälä; Carol Forsblom; Ron Liebkind; Turgut Tatlisumak; Lena M Thorn; Per-Henrik Groop; Sara Shams; Jukka Putaala; Juha Martola; Daniel Gordin Journal: Acta Diabetol Date: 2021-03-20 Impact factor: 4.280
Authors: Jussi Inkeri; Krishna Adeshara; Valma Harjutsalo; Carol Forsblom; Ron Liebkind; Turgut Tatlisumak; Lena M Thorn; Per-Henrik Groop; Sara Shams; Juha Martola; Jukka Putaala; Daniel Gordin Journal: Acta Diabetol Date: 2021-11-15 Impact factor: 4.280
Authors: Tor-Björn Claesson; Jukka Putaala; Sara Shams; Eero Salli; Daniel Gordin; Ron Liebkind; Carol Forsblom; Paula A Summanen; Turgut Tatlisumak; Per-Henrik Groop; Juha Martola; Lena M Thorn Journal: Front Neurol Date: 2020-01-29 Impact factor: 4.003