Leonid Emerel1, James Thunes2, Trevor Kickliter2, Marie Billaud3, Julie A Phillippi4, David A Vorp5, Spandan Maiti2, Thomas G Gleason6. 1. Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa. 2. Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pa. 3. Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pa; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pa. 4. Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pa; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pa; Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, Pa. 5. Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pa; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pa; Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, Pa; Department of Chemical & Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pa. 6. Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pa; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pa; Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, Pa; Center for Thoracic Aortic Disease, University of Pittsburgh, Pittsburgh, Pa. Electronic address: gleasontg@upmc.edu.
Abstract
OBJECTIVE: To assess ascending aortic distensibility and build geometry and distensibility-based patient-specific stress distribution maps in patients sustaining type A aortic dissection (TAAD) using predissection noninvasive imaging. METHODS: Review of charts from patients undergoing surgical repair of TAAD (n = 351) led to the selection of a subset population (n = 7) with 2 or more predissection computed tomography angiography scans and echocardiograms at least 1 year before dissection. Ascending aortic wall biomechanical properties (aortic strain, distensibility, and stiffness) were compared with age- and size-matched nondissected nonaneurysmal controls. Patient-specific aortic strain served as an input in aortic geometry-based simulated 3-dimensional reconstructions to generate longitudinal and circumferential wall stress maps. Inspection of perioperative dissection scans and intraoperative visual examination confirmed primary tear locations. RESULTS: Predissection echocardiography revealed ascending aortas of patients sustaining TAAD to exhibit decreased aortic wall strain (14.50 ± 1.13% vs 8.49 ± 1.08%; P < .01), decreased distensibility (4.26 ± 0.44 vs 2.39 ± 0.33 10-6 cm2·dyne-1; P < .01), increased stiffness (3.84 ± 0.24 vs 7.48 ± 1.05; P < .001), and increased longitudinal wall stress (246 ± 22 vs 172 ± 37 kPa; P < .01). There was no significant difference in circumferential wall stress. Predissection computed tomography angiography models revealed overlap between regions of increased longitudinal wall stress and primary tear sites. CONCLUSIONS: Using predissection imaging, we identified increased stiffness and longitudinal wall stress in ascending aortas of patients with dissection. Patient-specific imaging-derived biomechanical property maps like these may be instrumental toward designing better prediction models of aortic dissection potential.
OBJECTIVE: To assess ascending aortic distensibility and build geometry and distensibility-based patient-specific stress distribution maps in patients sustaining type A aortic dissection (TAAD) using predissection noninvasive imaging. METHODS: Review of charts from patients undergoing surgical repair of TAAD (n = 351) led to the selection of a subset population (n = 7) with 2 or more predissection computed tomography angiography scans and echocardiograms at least 1 year before dissection. Ascending aortic wall biomechanical properties (aortic strain, distensibility, and stiffness) were compared with age- and size-matched nondissected nonaneurysmal controls. Patient-specific aortic strain served as an input in aortic geometry-based simulated 3-dimensional reconstructions to generate longitudinal and circumferential wall stress maps. Inspection of perioperative dissection scans and intraoperative visual examination confirmed primary tear locations. RESULTS: Predissection echocardiography revealed ascending aortas of patients sustaining TAAD to exhibit decreased aortic wall strain (14.50 ± 1.13% vs 8.49 ± 1.08%; P < .01), decreased distensibility (4.26 ± 0.44 vs 2.39 ± 0.33 10-6 cm2·dyne-1; P < .01), increased stiffness (3.84 ± 0.24 vs 7.48 ± 1.05; P < .001), and increased longitudinal wall stress (246 ± 22 vs 172 ± 37 kPa; P < .01). There was no significant difference in circumferential wall stress. Predissection computed tomography angiography models revealed overlap between regions of increased longitudinal wall stress and primary tear sites. CONCLUSIONS: Using predissection imaging, we identified increased stiffness and longitudinal wall stress in ascending aortas of patients with dissection. Patient-specific imaging-derived biomechanical property maps like these may be instrumental toward designing better prediction models of aortic dissection potential.
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