Yongzhi Zhai1, Lu Gan2, Sai Huang3, Qinrui Xing4, Xuan Zhou5, Lili Wang6, Cong Feng7, Li Chen8, Tanshi Li9. 1. Department of Emergency, First Medical Center, General Hospital of the PLA, Haidian district, Beijing, 100853, China. Electronic address: fc194@163.com. 2. Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. Electronic address: 13805366900@126.com. 3. Department of Hematology, First Medical Center, General Hospital of the PLA, Beijing, 100853, China. Electronic address: helinahs@foxmail.com. 4. Department of Emergency, Hainan Branch Hospital of the PLA General Hospital, Sanya, 572000, China. Electronic address: honghaogao929@163.com. 5. Department of Emergency, First Medical Center, General Hospital of the PLA, Haidian district, Beijing, 100853, China. Electronic address: xuan081012@126.com. 6. Department of Emergency, First Medical Center, General Hospital of the PLA, Haidian district, Beijing, 100853, China. Electronic address: zaijiabei00988@126.com. 7. Department of Emergency, First Medical Center, General Hospital of the PLA, Haidian district, Beijing, 100853, China. Electronic address: congf@mit.edu. 8. Department of Emergency, First Medical Center, General Hospital of the PLA, Haidian district, Beijing, 100853, China. Electronic address: chenli-china@163.com. 9. Department of Emergency, First Medical Center, General Hospital of the PLA, Haidian district, Beijing, 100853, China. Electronic address: lts301@163.com.
Abstract
OBJECTIVES: To study the therapeutic effect of early peripancreatic lavage of ulinastatin on severe acute pancreatitis(SAP). METHODS: Sixteen pigs were divided into 4 groups: model(SAP), saline lavage(SL), ulinastatin lavage(UL), intravenous ulinastatin(IU). UL and SL group were given peripancreatic lavage of ulinastatin by ultrasound-guided perirenal catheterization and IU group was intravenously instilled with ulinastatin. The multi-organ functions and the inflammatory factors were observed. RESULTS: UL group has the best therapeutic effect. The changes of multi-organ functions and the inflammatory factors were compared with SAP group as follows. In time window of treatment: amylase (p < 0.01), lipase (p < 0.01), ALT (p > 0.05), AST (p < 0.05), CR (p < 0.01), UR (p < 0.01), IL-6 (p < 0.01), IL-10 (p < 0.01). In post-treatment phase: amylase (p < 0.01), lipase (p < 0.01), ALT (p < 0.01), AST (p < 0.01), CR (p < 0.05), UR (p > 0.05), IL-6 (p < 0.01), IL-10 (p < 0.01). CONCLUSIONS: Early peripancreatic lavage of ulinastatin in SAP could effectively improve the multi-organ functions and inflammatory response.
OBJECTIVES: To study the therapeutic effect of early peripancreatic lavage of ulinastatin on severe acute pancreatitis(SAP). METHODS: Sixteen pigs were divided into 4 groups: model(SAP), saline lavage(SL), ulinastatin lavage(UL), intravenous ulinastatin(IU). UL and SL group were given peripancreatic lavage of ulinastatin by ultrasound-guided perirenal catheterization and IU group was intravenously instilled with ulinastatin. The multi-organ functions and the inflammatory factors were observed. RESULTS: UL group has the best therapeutic effect. The changes of multi-organ functions and the inflammatory factors were compared with SAP group as follows. In time window of treatment: amylase (p < 0.01), lipase (p < 0.01), ALT (p > 0.05), AST (p < 0.05), CR (p < 0.01), UR (p < 0.01), IL-6 (p < 0.01), IL-10 (p < 0.01). In post-treatment phase: amylase (p < 0.01), lipase (p < 0.01), ALT (p < 0.01), AST (p < 0.01), CR (p < 0.05), UR (p > 0.05), IL-6 (p < 0.01), IL-10 (p < 0.01). CONCLUSIONS: Early peripancreatic lavage of ulinastatin in SAP could effectively improve the multi-organ functions and inflammatory response.