R Brannigan1, M Cannon2, A Tanskanen3,4, M O Huttunen3, F P Leacy5, M C Clarke1,2. 1. Department of Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland. 2. Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland. 3. Department of Mental Health, National Institute for Health and Welfare, Helsinki, Finland. 4. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. 5. Data Science Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.
Abstract
OBJECTIVE: Exposure to prenatal stress is a ubiquitous and non-specific risk factor for adverse outcomes in adulthood. In this study, we examined associations between exposure to subjective maternal stress during pregnancy and subsequent diagnosis of psychiatric disorders in offspring. METHOD: This study used the Helsinki Longitudinal Temperament Cohort, a prospective birth cohort of individuals born between 1 July 1975 and 30 June 1976 in Helsinki, Finland. The sample for this study comprised 3626 infants whose mothers had completed health and well-being assessments during pregnancy which included a measure of self-reported stress. We ran logistic regressions to assess potential associations between prenatal stress and offspring psychiatric disorder in adulthood, identified through the Finnish Hospital Discharge Register. RESULTS: Individuals whose mothers reported stress during pregnancy had significantly greater odds of developing a psychiatric disorder (OR = 1.41, 95% CI = 1.10-1.81) particularly a mood disorder (OR = 1.67, 95% CI = 1.10-2.54). These associations remained after adjusting for parental psychiatric history, and other prenatal factors. CONCLUSIONS: Individuals exposed to prenatal stress had significantly increased risk of developing psychiatric disorders later in life. This finding highlights the importance of supporting the mental health and emotional well-being of women during pregnancy.
OBJECTIVE: Exposure to prenatal stress is a ubiquitous and non-specific risk factor for adverse outcomes in adulthood. In this study, we examined associations between exposure to subjective maternal stress during pregnancy and subsequent diagnosis of psychiatric disorders in offspring. METHOD: This study used the Helsinki Longitudinal Temperament Cohort, a prospective birth cohort of individuals born between 1 July 1975 and 30 June 1976 in Helsinki, Finland. The sample for this study comprised 3626 infants whose mothers had completed health and well-being assessments during pregnancy which included a measure of self-reported stress. We ran logistic regressions to assess potential associations between prenatal stress and offspring psychiatric disorder in adulthood, identified through the Finnish Hospital Discharge Register. RESULTS: Individuals whose mothers reported stress during pregnancy had significantly greater odds of developing a psychiatric disorder (OR = 1.41, 95% CI = 1.10-1.81) particularly a mood disorder (OR = 1.67, 95% CI = 1.10-2.54). These associations remained after adjusting for parental psychiatric history, and other prenatal factors. CONCLUSIONS: Individuals exposed to prenatal stress had significantly increased risk of developing psychiatric disorders later in life. This finding highlights the importance of supporting the mental health and emotional well-being of women during pregnancy.
Authors: Ritika Sharma; Martin G Frasch; Silvia M Lobmaier; Marta C Antonelli; Camila Zelgert; Peter Zimmermann; Bibiana Fabre; Rory Wilson; Melanie Waldenberger; James W MacDonald; Theo K Bammler Journal: Clin Epigenetics Date: 2022-07-14 Impact factor: 7.259
Authors: Ross Brannigan; Antti Tanskanen; Matti O Huttunen; Mary Cannon; Finbarr P Leacy; Mary C Clarke Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2021-05-04 Impact factor: 4.328