Irene Arroyo-Solera1,2, Miguel Ángel Pavón3, Xavier León2,4, Montserrat López4, Alberto Gallardo5, María Virtudes Céspedes1,2, Isolda Casanova1,2, Víctor Pallarès6, Antonio López-Pousa2,7, María Antonia Mangues2,8, Agustí Barnadas7, Miquel Quer4, Ramón Mangues1,2. 1. Grup d'Oncogènesi i Antitumorals, lnstitut d'Investigacions Biomèdiques Sant Pau (IIB-Sant Pau), Barcelona, Spain. 2. Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomecidicina (CIBER-BBN), Barcelona, Spain. 3. Infection and Cancer Laboratory. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), IDIBELL and CIBER-ONC, Barcelona, Spain. 4. Department of Otorrinolaryngology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. 5. Department of Pathology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. 6. Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. 7. Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. 8. Department of Pharmacy, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Abstract
BACKGROUND: Serpin Family E Member 1 (SerpinE1) overexpression associates with poor clinical outcome in head and neck squamous cell carcinoma (HNSCC) patients. This study analyzed the role of serpinE1 in HNSCC dissemination. METHODS: We studied the phenotypic characteristics and dissemination of HNSCC cells overexpressing serpinE1 using an orthotopic model and the association between serpinE1 overexpression and clinicopathological variables in patients included in The Cancer Genome Atlas database. RESULTS: SerpinE1 overexpression increased proliferation, tumor budding, and the stromal component, while inhibiting apoptosis in primary tumors. It also enhanced the affectation and metastatic growth in lymph nodes, and the dispersion and growth of metastatic foci in the lung. High serpinE1 expression was associated with larger tumor size, undifferentiated tumors, lymph node metastasis, extracapsular spread, and the presence of perineural and angiolymphatic invasion. CONCLUSION: SerpinE1 overexpression promotes tumor aggressiveness and metastatic dissemination to lymph nodes and lung consistently with its association with poor outcome in HNSCC patients.
BACKGROUND:Serpin Family E Member 1 (SerpinE1) overexpression associates with poor clinical outcome in head and neck squamous cell carcinoma (HNSCC) patients. This study analyzed the role of serpinE1 in HNSCC dissemination. METHODS: We studied the phenotypic characteristics and dissemination of HNSCC cells overexpressing serpinE1 using an orthotopic model and the association between serpinE1 overexpression and clinicopathological variables in patients included in The Cancer Genome Atlas database. RESULTS:SerpinE1 overexpression increased proliferation, tumor budding, and the stromal component, while inhibiting apoptosis in primary tumors. It also enhanced the affectation and metastatic growth in lymph nodes, and the dispersion and growth of metastatic foci in the lung. High serpinE1 expression was associated with larger tumor size, undifferentiated tumors, lymph node metastasis, extracapsular spread, and the presence of perineural and angiolymphatic invasion. CONCLUSION:SerpinE1 overexpression promotes tumor aggressiveness and metastatic dissemination to lymph nodes and lung consistently with its association with poor outcome in HNSCCpatients.
Authors: Yongqian Zhang; Hongmin Wang; Feifei Wang; Wenhua Ma; Na Li; Changwen Bo; YingChun Zhao; Li He; Ming Liu Journal: Comput Math Methods Med Date: 2022-09-27 Impact factor: 2.809