Pishoy Gouda1,2, Justin A Ezekowitz1. 1. Division of Cardiology, Canadian VIGOUR Centre, University of Alberta, Edmonton. 2. Division of Internal Medicine, University of Calgary, Calgary, Alberta, Canada.
Abstract
PURPOSE OF REVIEW: To highlight the advances in the diagnosis and management of acute heart failure (AHF) from recent clinical trials and observational studies. RECENT FINDINGS: We highlight date from recent studies examining the use of novel biomarkers (micro RNAs, osteopontin, insulin-like growth-factor binding protein-7) for the diagnosis of AHF. In addition, we summarize the evidence for novel pharmacological therapies including: serelaxin, ularitide, clevidipine, urocortins, BMS-986231, TRB027, vericiguat, omecamtiv, and torsemide. Finally, we explore the evidence behind the use of novel management algorithms. SUMMARY: Despite many advances in understanding the pathophysiology of AHF, there is currently insufficient evidence to suggest changes to standards of care.
PURPOSE OF REVIEW: To highlight the advances in the diagnosis and management of acute heart failure (AHF) from recent clinical trials and observational studies. RECENT FINDINGS: We highlight date from recent studies examining the use of novel biomarkers (micro RNAs, osteopontin, insulin-like growth-factor binding protein-7) for the diagnosis of AHF. In addition, we summarize the evidence for novel pharmacological therapies including: serelaxin, ularitide, clevidipine, urocortins, BMS-986231, TRB027, vericiguat, omecamtiv, and torsemide. Finally, we explore the evidence behind the use of novel management algorithms. SUMMARY: Despite many advances in understanding the pathophysiology of AHF, there is currently insufficient evidence to suggest changes to standards of care.
Authors: Yasmina Bauer; Simon de Bernard; Peter Hickey; Karri Ballard; Jeremy Cruz; Peter Cornelisse; Harbajan Chadha-Boreham; Oliver Distler; Daniel Rosenberg; Martin Doelberg; Sebastien Roux; Oliver Nayler; Allan Lawrie Journal: Eur Respir J Date: 2021-06-24 Impact factor: 16.671
Authors: Piero Pollesello; Tuvia Ben Gal; Dominique Bettex; Vladimir Cerny; Josep Comin-Colet; Alexandr A Eremenko; Dimitrios Farmakis; Francesco Fedele; Cândida Fonseca; Veli-Pekka Harjola; Antoine Herpain; Matthias Heringlake; Leo Heunks; Trygve Husebye; Visnja Ivancan; Kristian Karason; Sundeep Kaul; Jacek Kubica; Alexandre Mebazaa; Henning Mølgaard; John Parissis; Alexander Parkhomenko; Pentti Põder; Gerhard Pölzl; Bojan Vrtovec; Mehmet B Yilmaz; Zoltan Papp Journal: J Clin Med Date: 2019-11-01 Impact factor: 4.241