Literature DB >> 30546606

Acute left ventricular dysfunction complicating pregnancy on ECMO: Tri-iodothyronine to the rescue with real time transesophageal echocardiography.

Gautam K Visveswaran1, Claudia Gidea2, David Baran2, Marc Cohen1, Mark J Zucker2.   

Abstract

Cardiac dysfunction is a common accompaniment to severe sepsis. Clinical management of the same complicating pregnancy presents unique challenges balancing maternal and fetal well-being. Can short-term intravenous (IV) tri-iodothyronine (T3) be used in the management of these patients? T3 has been reported in varied clinical settings to favorably affect cardiac lusitropy, inotropy, and chronotropy without significant side effects. We report a case of acute severe left ventricular dysfunction in a pregnant woman with severe acute respiratory distress syndrome on veno-venous extracorporeal membrane oxygenation managed with short-term IV T3. Hemodynamic stability was rapidly achieved and the improvement in contractility imaged in real time by transesophageal echocardiography. <Learning objective: Tri-iodothyronine (T3) rapidly affects cardiac inotropy, lusitropy, chronotropy, and systemic vascular resistance. Widespread application of intravenous T3 for treatment of heart failure is currently limited by a paucity of scientific literature. Selective short-term intravenous T3 use is an underutilized adjunct in the management of acute left ventricular dysfunction.>.

Entities:  

Keywords:  Cardiomyopathy; ECMO; Pregnancy; Transesophageal echocardiography; Tri-iodothyronine

Year:  2015        PMID: 30546606      PMCID: PMC6281893          DOI: 10.1016/j.jccase.2015.09.005

Source DB:  PubMed          Journal:  J Cardiol Cases        ISSN: 1878-5409


  12 in total

Review 1.  The role of thyroid hormone in the pathophysiology of heart failure: clinical evidence.

Authors:  E Galli; A Pingitore; G Iervasi
Journal:  Heart Fail Rev       Date:  2008-12-27       Impact factor: 4.214

2.  Alterations in cardiac contractility and gene expression during low-T3 syndrome: prevention with T3.

Authors:  H L Katzeff; S R Powell; K Ojamaa
Journal:  Am J Physiol       Date:  1997-11

3.  Glucose-insulin-potassium and tri-iodothyronine individually improve hemodynamic performance and are associated with reduced troponin I release after on-pump coronary artery bypass grafting.

Authors:  Aaron M Ranasinghe; David W Quinn; Domenico Pagano; Nicola Edwards; Muzzafar Faroqui; Timothy R Graham; Bruce E Keogh; Jorge Mascaro; David W Riddington; Stephen J Rooney; John N Townend; Ian C Wilson; Robert S Bonser
Journal:  Circulation       Date:  2006-07-04       Impact factor: 29.690

Review 4.  Thyroid function in critically ill patients.

Authors:  Eric Fliers; Antonio C Bianco; Lies Langouche; Anita Boelen
Journal:  Lancet Diabetes Endocrinol       Date:  2015-06-10       Impact factor: 32.069

5.  Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC): a multicenter placebo-controlled randomized trial: age analysis.

Authors:  Michael A Portman; April Slee; Aaron K Olson; Gordon Cohen; Tom Karl; Elizabeth Tong; Laura Hastings; Hitendra Patel; Olaf Reinhartz; Antonio R Mott; Richard Mainwaring; Justin Linam; Sara Danzi
Journal:  Circulation       Date:  2010-09-14       Impact factor: 29.690

Review 6.  Thyroid hormone metabolism in patients with congestive heart failure: the low triiodothyronine state.

Authors:  Deborah D Ascheim; Katarzyna Hryniewicz
Journal:  Thyroid       Date:  2002-06       Impact factor: 6.568

7.  Low-T3 syndrome: a strong prognostic predictor of death in patients with heart disease.

Authors:  Giorgio Iervasi; Alessandro Pingitore; Patrizia Landi; Mauro Raciti; Andrea Ripoli; Maria Scarlattini; Antonio L'Abbate; Luigi Donato
Journal:  Circulation       Date:  2003-02-11       Impact factor: 29.690

8.  Acute effects of triiodothyronine (T3) replacement therapy in patients with chronic heart failure and low-T3 syndrome: a randomized, placebo-controlled study.

Authors:  Alessandro Pingitore; Elena Galli; Andrea Barison; Annalisa Iervasi; Maria Scarlattini; Daniele Nucci; Antonio L'abbate; Rita Mariotti; Giorgio Iervasi
Journal:  J Clin Endocrinol Metab       Date:  2008-01-02       Impact factor: 5.958

Review 9.  Sepsis and the heart.

Authors:  M W Merx; C Weber
Journal:  Circulation       Date:  2007-08-14       Impact factor: 29.690

10.  Wait, treat and see: echocardiographic monitoring of brain-dead potential donors with stunned heart.

Authors:  Marilena Casartelli; Tonino Bombardini; Davide Simion; Maria Grazia Gaspari; Francesco Procaccio
Journal:  Cardiovasc Ultrasound       Date:  2012-06-21       Impact factor: 2.062

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  1 in total

1.  Extracorporeal Life Support in Pregnancy: A Systematic Review.

Authors:  Emily E Naoum; Andrew Chalupka; Jonathan Haft; Mark MacEachern; Cosmas J M Vandeven; Sarah Rae Easter; Michael Maile; Brian T Bateman; Melissa E Bauer
Journal:  J Am Heart Assoc       Date:  2020-06-24       Impact factor: 5.501

  1 in total

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