Hajar Adib Rad1, Zahra Basirat1, Fatemeh Bakouei1, Ali Akbar Moghadamnia2, Soraya Khafri3, Zeynab Farhadi Kotenaei4, Maryam Nikpour5, Somayeh Kazemi6. 1. Infertility and Health Reproductive Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Islamic Republic of Iran. 2. Cellular and Molecular Biology Research Center, Health Research Institute, Department of Pharmacology, Babol University of Medical Sciences, Babol, Islamic Republic of Iran. 3. Infertility and Health Reproductive Research Center, Health Research Institute, Department of Statistic and Epidemiology, Babol University of Medical Sciences, Babol, Islamic Republic of Iran. 4. Social Determinants of Health Research Center, Health Research Institute, Department of Nursing, Babol University of Medical Sciences, Babol, Islamic Republic of Iran. Electronic address: Farhadi_Zeynab@yahoo.com. 5. Social Determinants of Health Research Center, Health Research Institute, Department of Midwifery, Babol University of Medical Sciences, Babol, Islamic Republic of Iran. 6. Department of Midwifery, Babol University of Medical Sciences, Babol, Islamic Republic of Iran.
Abstract
OBJECTIVE:Menstrual pain is a periodic pain which happens during the days of menses. The menstrual disturbances as a health problem among young girls affect not only reproductive, but also psychical health and quality of life. This study was done with the goal of comparing the effect of Ginger and Novafen on the menstrual pain. MATERIALS AND METHODS: This crossover clinical trial study was done in Iran on 168 single girl students 18-26 years old in Babol University of Medical Sciences with primary menstrual pain. The participants were randomly allocated to two groups receiving the drugs Novafen and Ginger. At the beginning of pain, in the two groups 200 mg capsule was given every 6 h for two serial cycles. Pain severity was measured by the visual scale before treatment, 1 h after consuming the drug (for 24 h) and 48 h after the onset of drug. RESULTS:The mean age of participants was 21.83 ± 2.07 years. It has been reported that the intensity of pain from dysmenorrhea decreased in the Novafen and Ginger groups. Before treatment, the average pain intensity in Novafen and Ginger users were 7.12 ± 2.32 and 7.60 ± 1.84, respectively and after treatment pain intensity decreased to 3.10 ± 2.69 and 2.97 ± 2.69, respectively. Differences between two groups each time showed no statistical significance (p > 0.05). CONCLUSION: Both drugs reduced menstrual pain. Ginger as well as Novafen is effective in relieving pain in girls with primary dysmenorrhea . Therefore, treatment with natural herbal medicine, non-synthetic drug, to reduce primary dysmenorrhea is recommended.
RCT Entities:
OBJECTIVE:Menstrual pain is a periodic pain which happens during the days of menses. The menstrual disturbances as a health problem among young girls affect not only reproductive, but also psychical health and quality of life. This study was done with the goal of comparing the effect of Ginger and Novafen on the menstrual pain. MATERIALS AND METHODS: This crossover clinical trial study was done in Iran on 168 single girl students 18-26 years old in Babol University of Medical Sciences with primary menstrual pain. The participants were randomly allocated to two groups receiving the drugs Novafen and Ginger. At the beginning of pain, in the two groups 200 mg capsule was given every 6 h for two serial cycles. Pain severity was measured by the visual scale before treatment, 1 h after consuming the drug (for 24 h) and 48 h after the onset of drug. RESULTS: The mean age of participants was 21.83 ± 2.07 years. It has been reported that the intensity of pain from dysmenorrhea decreased in the Novafen and Ginger groups. Before treatment, the average pain intensity in Novafen and Ginger users were 7.12 ± 2.32 and 7.60 ± 1.84, respectively and after treatment pain intensity decreased to 3.10 ± 2.69 and 2.97 ± 2.69, respectively. Differences between two groups each time showed no statistical significance (p > 0.05). CONCLUSION: Both drugs reduced menstrual pain. Ginger as well as Novafen is effective in relieving pain in girls with primary dysmenorrhea . Therefore, treatment with natural herbal medicine, non-synthetic drug, to reduce primary dysmenorrhea is recommended.
Authors: Gene T Yocum; Julie J Hwang; Maya Mikami; Jennifer Danielsson; Aisha S Kuforiji; Charles W Emala Journal: Am J Physiol Lung Cell Mol Physiol Date: 2019-12-04 Impact factor: 5.464
Authors: Nguyen Hoang Anh; Sun Jo Kim; Nguyen Phuoc Long; Jung Eun Min; Young Cheol Yoon; Eun Goo Lee; Mina Kim; Tae Joon Kim; Yoon Young Yang; Eui Young Son; Sang Jun Yoon; Nguyen Co Diem; Hyung Min Kim; Sung Won Kwon Journal: Nutrients Date: 2020-01-06 Impact factor: 5.717