Literature DB >> 30543413

Cysteine-Directed Bioconjugation of a Platinum(II)-Acridine Anticancer Agent.

Xiyuan Yao1, Christopher M Tracy1, Ulrich Bierbach1.   

Abstract

Classical maleimide Michael addition chemistry in conjunction with copper-free click chemistry was investigated as a synthetic strategy to attach cytotoxic platinum-acridine hybrid agents to carrier proteins. The structural integrity and selectivity of the model payloads, which were validated in human serum albumin (HSA) using mass spectrometric analysis and heteronuclear 2D 1H-15N HSQC NMR experiments, may have broad utility for the targeted delivery of highly cytotoxic platinum acridines and other nonclassical platinum containing anticancer agents.

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Year:  2018        PMID： 30543413     DOI： 10.1021/acs.inorgchem.8b02717

Source DB:  PubMed          Journal:  Inorg Chem        ISSN： 0020-1669            Impact factor:   5.165


  4 in total

1.  Development of Novel 191Pt-Labeled Hoechst33258: 191Pt Is More Suitable than 111In for Targeting DNA.

Authors:  Honoka Obata; Atsushi B Tsuji; Katsushi Kumata; Hitomi Sudo; Katsuyuki Minegishi; Kotaro Nagatsu; Hideo Takakura; Mikako Ogawa; Akihiro Kurimasa; Ming-Rong Zhang
Journal:  J Med Chem       Date:  2022-03-31       Impact factor: 8.039

2.  Improving the anticancer activity of platinum(iv) prodrugs using a dual-targeting strategy with a dichloroacetate axial ligand.

Authors:  Fengfan Liu; Xiaomei Dong; Qiwen Shi; Jianli Chen; Weike Su
Journal:  RSC Adv       Date:  2019-07-17       Impact factor: 3.361

Review 3.  Exploiting azide-alkyne click chemistry in the synthesis, tracking and targeting of platinum anticancer complexes.

Authors:  Nicola J Farrer; Darren M Griffith
Journal:  Curr Opin Chem Biol       Date:  2020-01-13       Impact factor: 8.822

4.  Thermodynamic Insights by Microscale Thermophoresis into Translesion DNA Synthesis Catalyzed by DNA Polymerases Across a Lesion of Antitumor Platinum-Acridine Complex.

Authors:  Monika Hreusova; Olga Novakova; Viktor Brabec
Journal:  Int J Mol Sci       Date:  2020-10-21       Impact factor: 5.923
  4 in total

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