Adam Perlman1, Susan Gould Fogerite2, Oliver Glass3, Elizabeth Bechard3, Ather Ali4, Valentine Y Njike5, Carl Pieper3, Natalia O Dmitrieva6, Alison Luciano3, Lisa Rosenberger5, Teresa Keever3, Carl Milak2, Eric A Finkelstein7, Gwendolyn Mahon2, Giovanni Campanile8, Ann Cotter9, David L Katz5. 1. Duke Integrative Medicine, Durham, NC, USA. adam.perlman@duke.edu. 2. Rutgers School of Health Professions, Institute for Complementary and Alternative Medicine, Newark, NJ, USA. 3. Duke Integrative Medicine, Durham, NC, USA. 4. Yale School of Medicine, New Haven, CT, USA. 5. Yale-Griffin Prevention Research Center, Griffin Hospital, Yale University School of Public Health, Derby, CT, USA. 6. Department of Psychological Sciences, Northern Arizona University, Flagstaff, AZ, USA. 7. Duke-NUS Medical School, Singapore, Singapore. 8. Atlantic Integrative Medical Associates, Chambers Center for Well Being, Morristown, NJ, USA. 9. Veterans Administration New Jersey Health Care Center, East Orange, NJ, USA.
Abstract
BACKGROUND: Current treatment options for knee osteoarthritis have limited effectiveness and potentially adverse side effects. Massage may offer a safe and effective complement to the management of knee osteoarthritis. OBJECTIVE: Examine effects of whole-body massage on knee osteoarthritis, compared to active control (light-touch) and usual care. DESIGN: Multisite RCT assessing the efficacy of massage compared to light-touch and usual care in adults with knee osteoarthritis, with assessments at baseline and weeks 8, 16, 24, 36, and 52. Subjects in massage or light-touch groups received eight weekly treatments, then were randomized to biweekly intervention or usual care to week 52. The original usual care group continued to week 24. Analysis was performed on an intention-to-treat basis. PARTICIPANTS: Five hundred fifty-one screened for eligibility, 222 adults with knee osteoarthritis enrolled, 200 completed 8-week assessments, and 175 completed 52-week assessments. INTERVENTION: Sixty minutes of protocolized full-body massage or light-touch. MAIN MEASURES: Primary: Western Ontario and McMaster Universities Arthritis Index. Secondary: visual analog pain scale, PROMIS Pain Interference, knee range of motion, and timed 50-ft walk. KEY RESULTS: At 8 weeks, massage significantly improved WOMAC Global scores compared to light-touch (- 8.16, 95% CI = - 13.50 to - 2.81) and usual care (- 9.55, 95% CI = - 14.66 to - 4.45). Additionally, massage improved pain, stiffness, and physical function WOMAC subscale scores compared to light-touch (p < 0.001; p = 0.04; p = 0.02, respectively) and usual care (p < 0.001; p = 0.002; p = 0.002; respectively). At 52 weeks, the omnibus test of any group difference in the change in WOMAC Global from baseline to 52 weeks was not significant (p = 0.707, df = 3), indicating no significant difference in change across groups. Adverse events were minimal. CONCLUSIONS: Efficacy of symptom relief and safety of weekly massage make it an attractive short-term treatment option for knee osteoarthritis. Longer-term biweekly dose maintained improvement, but did not provide additional benefit beyond usual care post 8-week treatment. TRIAL REGISTRATION: clinicaltrials.gov NCT01537484.
RCT Entities:
BACKGROUND: Current treatment options for knee osteoarthritis have limited effectiveness and potentially adverse side effects. Massage may offer a safe and effective complement to the management of knee osteoarthritis. OBJECTIVE: Examine effects of whole-body massage on knee osteoarthritis, compared to active control (light-touch) and usual care. DESIGN: Multisite RCT assessing the efficacy of massage compared to light-touch and usual care in adults with knee osteoarthritis, with assessments at baseline and weeks 8, 16, 24, 36, and 52. Subjects in massage or light-touch groups received eight weekly treatments, then were randomized to biweekly intervention or usual care to week 52. The original usual care group continued to week 24. Analysis was performed on an intention-to-treat basis. PARTICIPANTS: Five hundred fifty-one screened for eligibility, 222 adults with knee osteoarthritis enrolled, 200 completed 8-week assessments, and 175 completed 52-week assessments. INTERVENTION: Sixty minutes of protocolized full-body massage or light-touch. MAIN MEASURES: Primary: Western Ontario and McMaster Universities Arthritis Index. Secondary: visual analog pain scale, PROMIS Pain Interference, knee range of motion, and timed 50-ft walk. KEY RESULTS: At 8 weeks, massage significantly improved WOMAC Global scores compared to light-touch (- 8.16, 95% CI = - 13.50 to - 2.81) and usual care (- 9.55, 95% CI = - 14.66 to - 4.45). Additionally, massage improved pain, stiffness, and physical function WOMAC subscale scores compared to light-touch (p < 0.001; p = 0.04; p = 0.02, respectively) and usual care (p < 0.001; p = 0.002; p = 0.002; respectively). At 52 weeks, the omnibus test of any group difference in the change in WOMAC Global from baseline to 52 weeks was not significant (p = 0.707, df = 3), indicating no significant difference in change across groups. Adverse events were minimal. CONCLUSIONS: Efficacy of symptom relief and safety of weekly massage make it an attractive short-term treatment option for knee osteoarthritis. Longer-term biweekly dose maintained improvement, but did not provide additional benefit beyond usual care post 8-week treatment. TRIAL REGISTRATION: clinicaltrials.gov NCT01537484.
Authors: R Altman; E Asch; D Bloch; G Bole; D Borenstein; K Brandt; W Christy; T D Cooke; R Greenwald; M Hochberg Journal: Arthritis Rheum Date: 1986-08
Authors: John Richmond; David Hunter; Jay Irrgang; Morgan H Jones; Bruce Levy; Robert Marx; Lynn Snyder-Mackler; William C Watters; Robert H Haralson; Charles M Turkelson; Janet L Wies; Kevin M Boyer; Sara Anderson; Justin St Andre; Patrick Sluka; Richard McGowan Journal: J Am Acad Orthop Surg Date: 2009-09 Impact factor: 3.020
Authors: Alex Tang Zhao; Cassidy J Caballero; Linh T Nguyen; Hunter C Vienne; Christopher Lee; Alan D Kaye Journal: Orthop Rev (Pavia) Date: 2022-05-31
Authors: Wang Wen-Yue; Xu Ying-Peng; Ding Quan-Mao; Xie Li-Min; Wang De-Zhi; Bai Yang; Wang Li-Su; Li Yu-Bin; Niu Zhi-Jun; Ma Yan-Xu; Chen Wu-Zhong; Bai Li-Qun; Liu Yang; Jin Li-Kun Journal: Trials Date: 2022-07-08 Impact factor: 2.728
Authors: Yuanshu Chen; Qin Li; Qianqian Zhang; Juan Kou; Yingying Zhang; Han Cui; Jennifer Wernicke; Christian Montag; Benjamin Becker; Keith M Kendrick; Shuxia Yao Journal: Front Neurosci Date: 2020-12-04 Impact factor: 4.677