| Literature DB >> 30540450 |
Changlong Hao1,2, Aihua Qu1,2, Liguang Xu1,2, Maozhong Sun1,2, Hongyu Zhang1,2, Chuanlai Xu1,2, Hua Kuang1,2.
Abstract
Reactive oxygen species (ROS)-mediated mitochondrial dysfunction is one of the major pathological mechanisms of Parkinson's disease. Using inorganic nanomaterials to scavenge ROS has drawn significant interest and can prevent ROS-mediated neurological disorders. We prepared uniform Cu xO nanoparticle clusters (NCs) with an average size of 65 ± 7 nm, using phenylalanine (Phe) as the structure-directing agent. These Cu xO NCs functionally mimicked the activities of peroxidase, superoxide dismutase, catalase, and glutathione peroxidase. Because they eliminated ROS, the Cu xO NCs inhibited neurotoxicity in a cellular model of Parkinson's disease and rescued the memory loss of mice with Parkinson's disease. The biocompatibility and multiple enzyme-mimicking activities of Cu xO NCs offer new opportunities for the application of NCs in biomedicine, biosensing, and biocatalysis.Entities:
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Year: 2018 PMID： 30540450 DOI： 10.1021/jacs.8b11856
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419