Literature DB >> 30540218

Brain tissue iron quantification by MRI in intracerebral hemorrhage: Current translational evidence and pitfalls.

Neeraj Chaudhary1,2, Aditya S Pandey1,2, Julius Griauzde1, Joseph J Gemmete1,2, Thomas L Chenevert1, Richard F Keep2, Guohua Xi2.   

Abstract

Intracerebral hemorrhage (ICH) is a common subtype of hemorrhagic stroke with devastating consequences with no specific treatment. There is, however, substantial evidence for iron-mediated neurotoxicity in animal ICH models. Non-invasive quantification of the peri-hematomal tissue iron based on MRI has shown some promise in animal models and is being validated for clinical translation. This commentary reviews evidence for this approach and discusses potential pitfalls.

Entities:  

Keywords:  ICH; Iron quantification; MRI; hemoglobin; translation

Year:  2018        PMID： 30540218      PMCID： PMC6421244          DOI： 10.1177/0271678X18818911

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  9 in total

1.  IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice.

Authors:  Jing Xu; Zhouqing Chen; Fang Yu; Huan Liu; Cheng Ma; Di Xie; Xiaoming Hu; Rehana K Leak; Sherry H Y Chou; R Anne Stetler; Yejie Shi; Jun Chen; Michael V L Bennett; Gang Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2020-12-08       Impact factor: 12.779

Review 2.  The Fate of Erythrocytes after Cerebral Hemorrhage.

Authors:  Fan Xia; Richard F Keep; Fenghui Ye; Katherine G Holste; Shu Wan; Guohua Xi; Ya Hua
Journal:  Transl Stroke Res       Date:  2022-01-23       Impact factor: 6.800

3.  Perihematomal brain tissue iron concentration measurement by MRI in patients with intracerebral hemorrhage.

Authors:  Jialiang Wei; Nemanja Novakovic; Thomas L Chenevert; Guohua Xi; Richard F Keep; Aditya S Pandey; Neeraj Chaudhary
Journal:  CNS Neurosci Ther       Date:  2020-05-21       Impact factor: 5.243

Review 4.  Molecular, Pathological, Clinical, and Therapeutic Aspects of Perihematomal Edema in Different Stages of Intracerebral Hemorrhage.

Authors:  Chao Jiang; Hengtao Guo; Zhiying Zhang; Yali Wang; Simon Liu; Jonathan Lai; Tom J Wang; Shize Li; Jing Zhang; Li Zhu; Peiji Fu; Jiewen Zhang; Jian Wang
Journal:  Oxid Med Cell Longev       Date:  2022-09-17       Impact factor: 7.310

5.  Endogenous zinc protoporphyrin formation critically contributes to hemorrhagic stroke-induced brain damage.

Authors:  Rong Pan; Song Yu; Haikun Zhang; Graham S Timmins; John Weaver; Yirong Yang; Xixi Zhou; Ke Jian Liu
Journal:  J Cereb Blood Flow Metab       Date:  2021-06-29       Impact factor: 6.960

6.  Intra-hematomal White Matter Tracts Act As a Scaffold for Macrophage Infiltration After Intracerebral Hemorrhage.

Authors:  Jingyin Chen; Sravanthi Koduri; Shuhui Dai; Yasunori Toyota; Ya Hua; Neeraj Chaudhary; Aditya S Pandey; Richard F Keep; Guohua Xi
Journal:  Transl Stroke Res       Date:  2020-10-22       Impact factor: 6.800

7.  Hemorrhagic stroke-Pathomechanisms of injury and therapeutic options.

Authors:  Neeraj Chaudhary; Aditya S Pandey; Xiaoying Wang; Guohua Xi
Journal:  CNS Neurosci Ther       Date:  2019-10       Impact factor: 5.243

8.  Assessing early erythrolysis and the relationship to perihematomal iron overload and white matter survival in human intracerebral hemorrhage.

Authors:  Nemanja Novakovic; Zachary M Wilseck; Thomas L Chenevert; Guohua Xi; Richard F Keep; Aditya S Pandey; Neeraj Chaudhary
Journal:  CNS Neurosci Ther       Date:  2021-06-17       Impact factor: 5.243

9.  Iron chelation suppresses secondary bleeding after intracerebral hemorrhage in angiotensin II-infused mice.

Authors:  Jie Wang; Xiao-Qin Tang; Min Xia; Cheng-Cheng Li; Chao Guo; Hong-Fei Ge; Yi Yin; Bo Wang; Wei-Xiang Chen; Hua Feng
Journal:  CNS Neurosci Ther       Date:  2021-08-04       Impact factor: 5.243
  9 in total

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