M L Woodward1, K M Gicas2, D E Warburton3, R F White4, A Rauscher5, O Leonova4, W Su4, G N Smith4, A E Thornton5, A T Vertinsky1, A A Phillips6, V M Goghari7, W G Honer4, D J Lang8. 1. Department of Radiology, University of British Columbia, Canada. 2. Department of Psychology, Simon Fraser University, Canada. 3. School of Kinesiology, University of British Columbia, Canada; Experimental Medicine Program, University of British Columbia, Canada. 4. Department of Psychiatry, University of British Columbia, Canada. 5. Department of Pediatrics, University of British Columbia, Canada. 6. School of Kinesiology, University of British Columbia, Canada. 7. Department of Psychology & Graduate Department of Psychological Clinical Science, University of Toronto, Canada. 8. Department of Radiology, University of British Columbia, Canada. Electronic address: dlang@mail.ubc.ca.
Abstract
BACKGROUND: Schizophrenia is associated with poor cognitive function and elevated cardiometabolic disease risk. These health concerns may exacerbate neurocognitive dysfunction associated with hippocampal abnormalities, particularly hippocampal volume reductions. Regular exercise is thought to improve symptom severity, reduce depression, and improve cognition in schizophrenia, and may trigger exercise-mediated hippocampal growth. The potential for the benefits of exercise for treatment-resistant schizophrenia patients has not been clearly assessed. This study aims to assess the effect of exercise on hippocampal plasticity and clinical outcomes in chronic schizophrenia. METHODS:Seventeen DSM-IV criteria schizophrenia or schizoaffective disorder patients completed a customized moderate intensity 12-week aerobic or weight-bearing exercise program. Adherence rates were 83% ± 9.4%) with 70% of participants completing the entire exercise program. Concomitant neuroimaging, clinical and cognitive assessments were obtained at baseline and 12-weeks. RESULTS: At follow-up, symptom severity scores (t(16) = -16.8, p. ≤ 0.0001) and social functioning (t(16) = 4.4, p. = 0.0004) improved. A trend for improved depression scores (t(16) = -2.0, p. = 0.06) with no change in anxiety, or extrapyramidal symptoms were seen. Hippocampal volume increased (t(16) = -2.54, p. = 0.02), specifically in the left CA-1 field (F(16) = -2.33, p. = 0.03). Hippocampal vascular volume was unchanged. Change in hippocampal volume and vascular volume was not significantly correlated with change in symptom severity or affect scores. CONCLUSIONS:Adjunct exercise may accelerate symptom improvement in treatment-resistant psychosis patients. While the underlying mechanism remains unclear, these results indicate that chronic schizophrenia patients experience hippocampal plasticity in response to exercise. STUDY REGISTRATION: Clinical Trials.govNCT01392885.
RCT Entities:
BACKGROUND:Schizophrenia is associated with poor cognitive function and elevated cardiometabolic disease risk. These health concerns may exacerbate neurocognitive dysfunction associated with hippocampal abnormalities, particularly hippocampal volume reductions. Regular exercise is thought to improve symptom severity, reduce depression, and improve cognition in schizophrenia, and may trigger exercise-mediated hippocampal growth. The potential for the benefits of exercise for treatment-resistant schizophreniapatients has not been clearly assessed. This study aims to assess the effect of exercise on hippocampal plasticity and clinical outcomes in chronic schizophrenia. METHODS: Seventeen DSM-IV criteria schizophrenia or schizoaffective disorderpatients completed a customized moderate intensity 12-week aerobic or weight-bearing exercise program. Adherence rates were 83% ± 9.4%) with 70% of participants completing the entire exercise program. Concomitant neuroimaging, clinical and cognitive assessments were obtained at baseline and 12-weeks. RESULTS: At follow-up, symptom severity scores (t(16) = -16.8, p. ≤ 0.0001) and social functioning (t(16) = 4.4, p. = 0.0004) improved. A trend for improved depression scores (t(16) = -2.0, p. = 0.06) with no change in anxiety, or extrapyramidal symptoms were seen. Hippocampal volume increased (t(16) = -2.54, p. = 0.02), specifically in the left CA-1 field (F(16) = -2.33, p. = 0.03). Hippocampal vascular volume was unchanged. Change in hippocampal volume and vascular volume was not significantly correlated with change in symptom severity or affect scores. CONCLUSIONS: Adjunct exercise may accelerate symptom improvement in treatment-resistant psychosispatients. While the underlying mechanism remains unclear, these results indicate that chronic schizophreniapatients experience hippocampal plasticity in response to exercise. STUDY REGISTRATION: Clinical Trials.govNCT01392885.
Authors: Shannon S D Bredin; Kai L Kaufman; Maddison I Chow; Donna J Lang; Nana Wu; David D Kim; Darren E R Warburton Journal: Front Cardiovasc Med Date: 2022-02-08
Authors: David D Kim; Donna J Lang; Darren E R Warburton; Alasdair M Barr; Randall F White; William G Honer; Ric M Procyshyn Journal: Pharmacy (Basel) Date: 2021-07-03
Authors: Sergi Papiol; Daniel Keeser; Alkomiet Hasan; Thomas Schneider-Axmann; Florian Raabe; Franziska Degenhardt; Moritz J Rossner; Heike Bickeböller; Ludovico Cantuti-Castelvetri; Mikael Simons; Thomas Wobrock; Andrea Schmitt; Berend Malchow; Peter Falkai Journal: Transl Psychiatry Date: 2019-11-11 Impact factor: 6.222