Literature DB >> 30539579

Determination of Autoantibodies to Transglutaminase by Electrochemiluminescence (ECL) Assay.

Zhiyuan Zhao1,2, Yong Gu1,3, Dongmei Miao1, Eric Hoffmeyer1, Yu Liu2, Liping Yu4.   

Abstract

Appearance of autoantibodies to tissue transglutaminase (TGA) is the most reliable biomarker to identify celiac disease autoimmunity. A nonradioactive assay of determination of TGA was newly developed using electrochemiluminescence (ECL) technology. This ECL assay has been demonstrated to be more sensitive than current standard radio-binding assay (RBA) in detecting TGA and can detect TGA earlier among high-risk young children followed from birth.

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Keywords:  Autoantibodies; Celiac disease; ECL assay; Tissue transglutaminase

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Year:  2019        PMID: 30539579     DOI: 10.1007/978-1-4939-8949-2_16

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN: 1064-3745


  1 in total

1.  A Phase 1 Study of KHK4083: A Single-Blind, Randomized, Placebo-Controlled Single-Ascending-Dose Study in Healthy Adults and an Open-Label Multiple-Dose Study in Patients With Ulcerative Colitis.

Authors:  Kenichi Furihata; Yoh Ishiguro; Naoki Yoshimura; Hiroaki Ito; Shinji Katsushima; Etsuji Kaneko; Munetake Shimabe; Mayumi Mukai; Risa Watanabe; Takuya Morishige
Journal:  Clin Pharmacol Drug Dev       Date:  2021-01-29
  1 in total

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