Literature DB >> 30539254

Diagnostics, treatment, and immune response in BK polyomavirus infection after pediatric kidney transplantation.

Thurid Ahlenstiel-Grunow1, Lars Pape2.   

Abstract

After pediatric kidney transplantation BK polyomavirus (BKPyV) infections are associated with an increased risk of graft loss by BKPyV-associated nephropathy (BkPyVAN). However, suitable prognostic markers for the individual outcome of BKPyV infections are missing and the management of therapeutic interventions remains a challenge to the success of pediatric kidney transplantation. This review gives an overview on current diagnostic and therapeutic strategies in the field of BKPyV infections after pediatric kidney transplantation. Methods determining the individual immune response to BKPyV are described and their usability is discussed. There is growing evidence that BKPyV-specific T cells (BKPyV-Tvis) may serve as prognostic markers in order to steer immunosuppressive therapy in pediatric kidney recipients with BKPyV viremia in future. Prospective randomized trials in viremic kidney recipients comparing Tvis-steered therapeutic intervention with standard reduction of immunosuppression are needed before implementation of BKPyV-Tvis monitoring in routine care of BKPyV infections.

Entities:  

Keywords:  BK polyomavirus; BK polyomavirus-associated nephropathy; Immunosuppression; Kidney transplantation; Pediatric transplantation; Prognostic marker; Viral infections; Virus-specific T cells; mTOR inhibitors

Year:  2018        PMID： 30539254     DOI： 10.1007/s00467-018-4164-3

Source DB:  PubMed          Journal:  Pediatr Nephrol        ISSN： 0931-041X            Impact factor:   3.714


  61 in total

1.  Evaluation of fluoroquinolones for the prevention of BK viremia after renal transplantation.

Authors:  Steven Gabardi; Sushrut S Waikar; Spencer Martin; Keri Roberts; Jie Chen; Lea Borgi; Hussein Sheashaa; Christine Dyer; Sayeed K Malek; Stefan G Tullius; Nidyanandh Vadivel; Monica Grafals; Reza Abdi; Nader Najafian; Edgar Milford; Anil Chandraker
Journal:  Clin J Am Soc Nephrol       Date:  2010-05-27       Impact factor: 8.237

Review 2.  Polyomavirus-associated nephropathy: update on antiviral strategies.

Authors:  M A Josephson; J W Williams; A Chandraker; P S Randhawa
Journal:  Transpl Infect Dis       Date:  2006-06       Impact factor: 2.228

3.  A single-centre study of adjuvant cidofovir therapy for BK virus interstitial nephritis (BKVIN) in renal allograft recipients.

Authors:  Dirk R J Kuypers; Bert Bammens; Kathleen Claes; Pieter Evenepoel; Evelyne Lerut; Yves Vanrenterghem
Journal:  J Antimicrob Chemother       Date:  2008-12-04       Impact factor: 5.790

4.  Inflammatory activation and recovering BKV-specific immunity correlate with self-limited BKV replication after renal transplantation.

Authors:  Thomas Schachtner; Maik Stein; Anett Sefrin; Nina Babel; Petra Reinke
Journal:  Transpl Int       Date:  2013-12-17       Impact factor: 3.782

5.  PD-1 expression and IL-2 loss of cytomegalovirus- specific T cells correlates with viremia and reversible functional anergy.

Authors:  U Sester; D Presser; J Dirks; B C Gärtner; H Köhler; M Sester
Journal:  Am J Transplant       Date:  2008-07       Impact factor: 8.086

Review 6.  Role of mTOR inhibitors for the control of viral infection in solid organ transplant recipients.

Authors:  Julio Pascual; Ana Royuela; Ana M Fernández; Ignacio Herrero; Juan F Delgado; Amparo Solé; Lluis Guirado; Trinidad Serrano; Julián de la Torre-Cisneros; Asunción Moreno; Elisa Cordero; Roberto Gallego; Carlos Lumbreras; José M Aguado
Journal:  Transpl Infect Dis       Date:  2016-10-19       Impact factor: 2.228

7.  Influence of surveillance renal allograft biopsy on diagnosis and prognosis of polyomavirus-associated nephropathy.

Authors:  Christopher K Buehrig; Donna J Lager; Mark D Stegall; Michelle A Kreps; Walter K Kremers; James M Gloor; Thomas R Schwab; Jorge A Velosa; Mary E Fidler; Timothy S Larson; Matthew D Griffin
Journal:  Kidney Int       Date:  2003-08       Impact factor: 10.612

8.  Treatment of renal allograft polyoma BK virus infection with leflunomide.

Authors:  Michelle A Josephson; Daniel Gillen; Basit Javaid; Pradeep Kadambi; Shane Meehan; Preston Foster; Robert Harland; Richard J Thistlethwaite; Marc Garfinkel; Walter Atwood; Joslynn Jordan; Molly Sadhu; Michael J Millis; James Williams
Journal:  Transplantation       Date:  2006-03-15       Impact factor: 4.939

9.  Interplay of cellular and humoral immune responses against BK virus in kidney transplant recipients with polyomavirus nephropathy.

Authors:  Yiping Chen; Jennifer Trofe; Jennifer Gordon; Renaud A Du Pasquier; Prabir Roy-Chaudhury; Marcelo J Kuroda; E Steve Woodle; Kamel Khalili; Igor J Koralnik
Journal:  J Virol       Date:  2006-04       Impact factor: 5.103

10.  Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40.

Authors:  Wendy A Knowles; Pam Pipkin; Nick Andrews; Andrew Vyse; Philip Minor; David W G Brown; Elizabeth Miller
Journal:  J Med Virol       Date:  2003-09       Impact factor: 2.327
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  3 in total

1.  Immunosuppression, BK polyomavirus infections, and BK polyomavirus-specific T cells after pediatric kidney transplantation.

Authors:  Thurid Ahlenstiel-Grunow; Lars Pape
Journal:  Pediatr Nephrol       Date:  2019-12-19       Impact factor: 3.714

2.  Steering Transplant Immunosuppression by Measuring Virus-Specific T Cell Levels: The Randomized, Controlled IVIST Trial.

Authors:  Thurid Ahlenstiel-Grunow; Xiaofei Liu; Raphael Schild; Jun Oh; Christina Taylan; Lutz T Weber; Hagen Staude; Murielle Verboom; Christoph Schröder; Ruxandra Sabau; Anika Großhennig; Lars Pape
Journal:  J Am Soc Nephrol       Date:  2020-12-15       Impact factor: 10.121

Review 3.  Virus-specific T cells in pediatric renal transplantation.

Authors:  Thurid Ahlenstiel-Grunow; Lars Pape
Journal:  Pediatr Nephrol       Date:  2020-03-27       Impact factor: 3.714
  3 in total

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