Dana Prídavková1, Matej Samoš2, Ivana Kazimierová3, Ľudovít Šutarík2, Soňa Fraňová3, Peter Galajda2, Marián Mokáň2. 1. Clinic of Internal Medicine, Jessenius Faculty of Medicine in Martin (JFM CU), Comenius University in Bratislava, Bratislava, Slovakia, danapridavkova@gmail.com. 2. Clinic of Internal Medicine, Jessenius Faculty of Medicine in Martin (JFM CU), Comenius University in Bratislava, Bratislava, Slovakia. 3. 1Biomedical Centre Martin JFM CU and 2Department of Pharmacology JFM CU, Jessenius Faculty of Medicine in Martin (JFM CU), Comenius University in Bratislava, Bratislava, Slovakia.
Abstract
BACKGROUND: To report changes in body composition and biochemical parameters in patients with type 1 diabetes mellitus (T1D) after switching from multiple daily injection (MDI) to continuous subcutaneous insulin infusion (CSII). METHODS: 31 patients switched over from MDI to CSII. Body composition, biochemical parameters, glycaemic variability (GV) and level of physical activity were evaluated before and 6 months on CSII. RESULTS: In both sexes, we found an increase in skeletal muscle mass (SMM), (p = 0.008; 0.008). In men, there was mainly a decrease in visceral fat area (VFA), (p = 0.028) and in women there was decrease of total body fat (TBF), (p = 0.020) and non-significant decrease of VFA (p = 0.098). SMM inversely correlated with VFA in men (p = -0.001) and with TBF in women (p = -0.005 ). GV was decreased generally and correlated inversely with TBF in men only (p = -0.026). Physical activity was increased and correlated inversely with VFA in men (p = -0.002) and in women (p = -0.006). CONCLUSIONS: Using CSII in T1D leads to a significant increase of SMM in both sexes to a decrease of VFA in men and to a non-significant decrease of VFA in women. Changes in adipose tissue and SMM were also related to increased physical activity and to decreased GV.
BACKGROUND: To report changes in body composition and biochemical parameters in patients with type 1 diabetes mellitus (T1D) after switching from multiple daily injection (MDI) to continuous subcutaneous insulin infusion (CSII). METHODS: 31 patients switched over from MDI to CSII. Body composition, biochemical parameters, glycaemic variability (GV) and level of physical activity were evaluated before and 6 months on CSII. RESULTS: In both sexes, we found an increase in skeletal muscle mass (SMM), (p = 0.008; 0.008). In men, there was mainly a decrease in visceral fat area (VFA), (p = 0.028) and in women there was decrease of total body fat (TBF), (p = 0.020) and non-significant decrease of VFA (p = 0.098). SMM inversely correlated with VFA in men (p = -0.001) and with TBF in women (p = -0.005 ). GV was decreased generally and correlated inversely with TBF in men only (p = -0.026). Physical activity was increased and correlated inversely with VFA in men (p = -0.002) and in women (p = -0.006). CONCLUSIONS: Using CSII in T1D leads to a significant increase of SMM in both sexes to a decrease of VFA in men and to a non-significant decrease of VFA in women. Changes in adipose tissue and SMM were also related to increased physical activity and to decreased GV.
Authors: Yves Reznik; Ohad Cohen; Ronnie Aronson; Ignacio Conget; Sarah Runzis; Javier Castaneda; Scott W Lee Journal: Lancet Date: 2014-07-02 Impact factor: 79.321
Authors: Vanessa Zen; Flávio D Fuchs; Marco V Wainstein; Sandro C Gonçalves; Karina Biavatti; Charles E Riedner; Felipe C Fuchs; Rodrigo V Wainstein; Ernani L Rhoden; Jorge P Ribeiro; Sandra C Fuchs Journal: Am J Cardiovasc Dis Date: 2012-10-25
Authors: Maria J Redondo; Alejandro F Siller; Xiangjun Gu; Mustafa Tosur; Melissa Bondy; Sridevi Devaraj; Stephanie Sisley Journal: BMJ Open Diabetes Res Care Date: 2020-10