Literature DB >> 30537705

Biology of Nodal Spread in Colon Cancer: Insights from Molecular and Genetic Studies.

Pridvi Kandagatla1, Lilias H Maguire2, Karin M Hardiman3.   

Abstract

Colorectal cancer (CRC) lymph node metastases are common but their genetics and the mechanism whereby these metastases occur are not well understood. Here we present recent data regarding genetic heterogeneity in primary CRCs and their metastasis. In addition, we explain the different potential models describing the mechanisms of metastasis and the data supporting them. Multiple studies have also revealed a variety of prognostic molecular markers that are associated with lymph node metastasis in CRC. A better understanding of genetic heterogeneity and the mechanisms of metastasis is critical to predicting clinical response and resistance to targeted therapy.
© 2018 S. Karger AG, Basel.

Entities:  

Keywords:  Cancer genetics; Colorectal cancer; Intratumor heterogeneity; Lymph node metastasis

Mesh：

Substances：

Year:  2018        PMID： 30537705      PMCID： PMC6542270          DOI： 10.1159/000494832

Source DB:  PubMed          Journal:  Eur Surg Res        ISSN： 0014-312X            Impact factor:   1.745


  33 in total

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Authors:  E R Fearon; B Vogelstein
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3.  Tissue-based proteomics reveals FXYD3, S100A11 and GSTM3 as novel markers for regional lymph node metastasis in colon cancer.

Authors:  Stephan Meding; Benjamin Balluff; Mareike Elsner; Cédrik Schöne; Sandra Rauser; Ulrich Nitsche; Matthias Maak; Alexander Schäfer; Stefanie M Hauck; Marius Ueffing; Rupert Langer; Heinz Höfler; Helmut Friess; Robert Rosenberg; Axel Walch
Journal:  J Pathol       Date:  2012-05-23       Impact factor: 7.996

4.  KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

Authors:  Astrid Lièvre; Jean-Baptiste Bachet; Delphine Le Corre; Valérie Boige; Bruno Landi; Jean-François Emile; Jean-François Côté; Gorana Tomasic; Christophe Penna; Michel Ducreux; Philippe Rougier; Frédérique Penault-Llorca; Pierre Laurent-Puig
Journal:  Cancer Res       Date:  2006-04-15       Impact factor: 12.701

5.  Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters.

Authors:  François Bertucci; Sébastien Salas; Séverine Eysteries; Valéry Nasser; Pascal Finetti; Christophe Ginestier; Emmanuelle Charafe-Jauffret; Béatrice Loriod; Loïc Bachelart; Jérôme Montfort; Geneviève Victorero; Frédéric Viret; Vincent Ollendorff; Vincent Fert; Marc Giovaninni; Jean-Robert Delpero; Catherine Nguyen; Patrice Viens; Geneviève Monges; Daniel Birnbaum; Rémi Houlgatte
Journal:  Oncogene       Date:  2004-02-19       Impact factor: 9.867

6.  Gene expression signature and the prediction of lymph node metastasis in colorectal cancer by DNA microarray.

Authors:  Toshiaki Watanabe; Takashi Kobunai; Toshiaki Tanaka; Soichiro Ishihara; Keiji Matsuda; Hirokazu Nagawa
Journal:  Dis Colon Rectum       Date:  2009-12       Impact factor: 4.585

7.  Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases.

Authors:  Stephan E Baldus; Karl-L Schaefer; Rainer Engers; Dinah Hartleb; Nikolas H Stoecklein; Helmut E Gabbert
Journal:  Clin Cancer Res       Date:  2010-01-26       Impact factor: 12.531

8.  Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

Authors:  Marco Gerlinger; Andrew J Rowan; Stuart Horswell; James Larkin; David Endesfelder; Eva Gronroos; Pierre Martinez; Nicholas Matthews; Aengus Stewart; Charles Swanton; M Math; Patrick Tarpey; Ignacio Varela; Benjamin Phillimore; Sharmin Begum; Neil Q McDonald; Adam Butler; David Jones; Keiran Raine; Calli Latimer; Claudio R Santos; Mahrokh Nohadani; Aron C Eklund; Bradley Spencer-Dene; Graham Clark; Lisa Pickering; Gordon Stamp; Martin Gore; Zoltan Szallasi; Julian Downward; P Andrew Futreal
Journal:  N Engl J Med       Date:  2012-03-08       Impact factor: 91.245

9.  The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers.

Authors:  Luis A Diaz; Richard T Williams; Jian Wu; Isaac Kinde; J Randolph Hecht; Jordan Berlin; Benjamin Allen; Ivana Bozic; Johannes G Reiter; Martin A Nowak; Kenneth W Kinzler; Kelly S Oliner; Bert Vogelstein
Journal:  Nature       Date:  2012-06-28       Impact factor: 49.962

10.  Distant metastasis occurs late during the genetic evolution of pancreatic cancer.

Authors:  Shinichi Yachida; Siân Jones; Ivana Bozic; Tibor Antal; Rebecca Leary; Baojin Fu; Mihoko Kamiyama; Ralph H Hruban; James R Eshleman; Martin A Nowak; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; Christine A Iacobuzio-Donahue
Journal:  Nature       Date:  2010-10-28       Impact factor: 49.962
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  1 in total

1.  Identification of Differently Expressed Genes Associated With Prognosis and Growth in Colon Adenocarcinoma Based on Integrated Bioinformatics Analysis.

Authors:  Ming Hu; Xiandong Fu; Zhaoming Si; Chunming Li; Jihu Sun; Xinna Du; Hu Zhang
Journal:  Front Genet       Date:  2019-12-04       Impact factor: 4.599
  1 in total

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