M Catalina Camacho1, Helmet T Karim2, Susan B Perlman3. 1. Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: mccamacho@pitt.edu. 2. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. 3. Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Abstract
BACKGROUND: Adaptive emotion processing is critical for nearly all aspects of social and emotional functioning. There are distinct developmental trajectories associated with improved emotion processing, with a protracted developmental course for negative or complex emotions. The specific changes in neural circuitry that underlie this development, however are still scarcely understood. We employed a multivariate approach in order to elucidate distinctions in complex, naturalistic emotion processing between childhood and adulthood. METHOD: Twenty-one adults (M±SD age = 26.57 ± 5.08 years) and thirty children (age = 7.75 ± 1.80 years) completed a free-viewing movie task during BOLD fMRI scanning. This task was designed to assess naturalistic processing of movie clips portraying positive, negative, and neutral emotions. Multivariate support vector machines (SVM) were trained to classify age groups based on neural activation during the task. RESULTS: SVMs were able to successfully classify condition (positive, negative, and neutral) across all participants with high accuracy (61.44%). SVMs could successfully distinguish adults and children within each condition (ps < 0.05). Regions that informed the age group SVMs were associated with sensory and socio-emotional processing (inferior parietal lobule), emotion regulation (inferior frontal gyrus), and sensory regions of the temporal and occipital lobes. CONCLUSIONS: These results point to distributed differences in activation between childhood and adulthood unique to each emotional condition. In the negative condition specifically, there is evidence for a shift in engagement from regions of sensory and socio-emotional integration to emotion regulation regions between children and adults. These results provide insight into circuitry contributing to maturation of emotional processing across development.
BACKGROUND: Adaptive emotion processing is critical for nearly all aspects of social and emotional functioning. There are distinct developmental trajectories associated with improved emotion processing, with a protracted developmental course for negative or complex emotions. The specific changes in neural circuitry that underlie this development, however are still scarcely understood. We employed a multivariate approach in order to elucidate distinctions in complex, naturalistic emotion processing between childhood and adulthood. METHOD: Twenty-one adults (M±SD age = 26.57 ± 5.08 years) and thirty children (age = 7.75 ± 1.80 years) completed a free-viewing movie task during BOLD fMRI scanning. This task was designed to assess naturalistic processing of movie clips portraying positive, negative, and neutral emotions. Multivariate support vector machines (SVM) were trained to classify age groups based on neural activation during the task. RESULTS: SVMs were able to successfully classify condition (positive, negative, and neutral) across all participants with high accuracy (61.44%). SVMs could successfully distinguish adults and children within each condition (ps < 0.05). Regions that informed the age group SVMs were associated with sensory and socio-emotional processing (inferior parietal lobule), emotion regulation (inferior frontal gyrus), and sensory regions of the temporal and occipital lobes. CONCLUSIONS: These results point to distributed differences in activation between childhood and adulthood unique to each emotional condition. In the negative condition specifically, there is evidence for a shift in engagement from regions of sensory and socio-emotional integration to emotion regulation regions between children and adults. These results provide insight into circuitry contributing to maturation of emotional processing across development.
Authors: Lucinda M Sisk; Kristina M Rapuano; May I Conley; Abigail S Greene; Corey Horien; Monica D Rosenberg; Dustin Scheinost; R Todd Constable; Charles E Glatt; B J Casey; Dylan G Gee Journal: J Neurosci Res Date: 2021-09-08 Impact factor: 4.164
Authors: Ru Zhang; Joseph Aloi; Sahil Bajaj; Johannah Bashford-Largo; Jennie Lukoff; Amanda Schwartz; Jamie Elowsky; Matthew Dobbertin; Karina S Blair; R James R Blair Journal: Psychol Med Date: 2021-09-01 Impact factor: 7.723
Authors: M Catalina Camacho; Elizabeth M Williams; Dori Balser; Ruchika Kamojjala; Nikhil Sekar; David Steinberger; Sishir Yarlagadda; Susan B Perlman; Deanna M Barch Journal: Affect Sci Date: 2022-01-20
Authors: J Elowsky; S Bajaj; J Bashford-Largo; R Zhang; A Mathur; A Schwartz; M Dobbertin; K S Blair; E Leibenluft; D Pardini; R J R Blair Journal: Child Adolesc Psychiatry Ment Health Date: 2022-05-23 Impact factor: 7.494
Authors: M Catalina Camacho; Lucy S King; Amar Ojha; Cheyenne M Garcia; Lucinda M Sisk; Anna C Cichocki; Kathryn L Humphreys; Ian H Gotlib Journal: Dev Sci Date: 2019-12-30
Authors: Kathleen I Crum; Soonjo Hwang; Karina S Blair; Joseph M Aloi; Harma Meffert; Stuart F White; Patrick M Tyler; Ellen Leibenluft; Kayla Pope; R J R Blair Journal: Psychol Med Date: 2020-06-25 Impact factor: 7.723
Authors: Ru Zhang; Johannah Bashford-Largo; Jennie Lukoff; Jaimie Elowsky; Erin Carollo; Amanda Schwartz; Matthew Dobbertin; Sahil Bajaj; Karina S Blair; Ellen Leibenluft; R James R Blair Journal: Front Psychiatry Date: 2021-11-16 Impact factor: 4.157
Authors: William J Mitchell; Lindsey J Tepfer; Nicole M Henninger; Susan B Perlman; Vishnu P Murty; Chelsea Helion Journal: Soc Cogn Affect Neurosci Date: 2021-07-31 Impact factor: 3.436